Endocrine disorders linked to chronic kidney disease: Mechanisms and clinical implications

doi:10.5527/wjn.v15.i1.113875

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World Journal of Nephrology

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Nephrol. Mar 25, 2026; 15(1): 113875
Published online Mar 25, 2026. doi: 10.5527/wjn.v15.i1.113875

Endocrine disorders linked to chronic kidney disease: Mechanisms and clinical implications

Marcio J Concepción-Zavaleta, Jenyfer M Fuentes-Mendoza, Elida P López-Ramírez, Jesús A Martínez-García, Luis A Concepción-Urteaga, José Paz-Ibarra

Marcio J Concepción-Zavaleta, Jenyfer M Fuentes-Mendoza, Grupo de Investigación en Neurociencias, Metabolismo, Efectividad Clínica y Sanitaria, Universidad Científica del Sur, Lima 15067, Peru

Elida P López-Ramírez, Jesús A Martínez-García, School of Medicine, Universidad Autónoma de San Luis Potosí, San Luis Potosi 2405, Mexico

Luis A Concepción-Urteaga, School of Medicine, Universidad Nacional de Trujillo, Trujillo 13011, La Libertad, Peru

José Paz-Ibarra, Department of Endocrinology, Hospital Nacional Edgardo Rebagliati Martins, Lima 15072, Peru

José Paz-Ibarra, School of Medicine, Universidad Nacional Mayor de San Marcos, Lima 15081, Peru

Co-first authors: Marcio J Concepción-Zavaleta and Jenyfer M Fuentes-Mendoza.

Author contributions: Concepción-Zavaleta MJ supervised the entire process; Concepción-Zavaleta MJ and Fuentes-Mendoza JM conceived and designed the study, they contributed equally to this article, they are the co-first authors of this manuscript; López-Ramírez EP, Martínez-García JA, Concepción-Urteaga LA, and Paz-Ibarra J conducted the literature search and data collection; Fuentes-Mendoza JM, López-Ramírez EP, and Martínez-García JA drafted the initial manuscript; Concepción-Zavaleta MJ, Concepción-Urteaga LA, and Paz-Ibarra J critically revised the manuscript for important intellectual content; and all authors read and approved the final version of the manuscript.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Corresponding author: Marcio J Concepción-Zavaleta, MD, Grupo de Investigación en Neurociencias, Metabolismo, Efectividad Clínica y Sanitaria, Universidad Científica del Sur, 19 Panamericana Sur Km, Villa El Salvador, Lima 15067, Peru. mconcepcion@cientifica.edu.pe

Received: September 5, 2025
Revised: September 26, 2025
Accepted: December 15, 2025
Published online: March 25, 2026
Processing time: 190 Days and 5.9 Hours

Core Tip

Core Tip: Chronic kidney disease disrupts multiple endocrine pathways, leading to mineral and bone disorders, thyroid dysfunction, hypogonadism, insulin resistance, and prolactin elevation. These hormonal disturbances exacerbate cardiovascular disease, anemia, sarcopenia, and impaired quality of life. This narrative review synthesizes current evidence on mechanisms, diagnostic challenges, and therapeutic strategies for endocrine complications in chronic kidney disease. By highlighting the bidirectional relationship between kidney and endocrine dysfunction, it underscores the need for integrated nephrology-endocrinology management to optimize patient outcomes.