Rajput M, Bachani S, Suri J, Bharti R, Kumar A, Kumar R, Verma H, Prasad P. Acute kidney injury associated with acute fatty liver of pregnancy: An update on a rare clinical entity. World J Nephrol 2025; 14(4): 110414 [DOI: 10.5527/wjn.v14.i4.110414]
Corresponding Author of This Article
Adarsh Kumar, DM, MD, Associate Professor, Department of Nephrology and Renal Transplant Medicine, Vardhman Mahavir Medical College and Safdarjung Hospital, Ansari Nagar East, Near AIIMS Metro Station, New Delhi 110029, Delhi, India. adarshnephro081@gmail.com
Research Domain of This Article
Urology & Nephrology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Dec 25, 2025 (publication date) through Dec 23, 2025
Times Cited of This Article
Times Cited (0)
Journal Information of This Article
Publication Name
World Journal of Nephrology
ISSN
2220-6124
Publisher of This Article
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Share the Article
Rajput M, Bachani S, Suri J, Bharti R, Kumar A, Kumar R, Verma H, Prasad P. Acute kidney injury associated with acute fatty liver of pregnancy: An update on a rare clinical entity. World J Nephrol 2025; 14(4): 110414 [DOI: 10.5527/wjn.v14.i4.110414]
Meenakshi Rajput, Sumitra Bachani, Jyotsna Suri, Rekha Bharti, Department of Obstetrics and Gynaecology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi 110029, Delhi, India
Adarsh Kumar, Rajesh Kumar, Himanshu Verma, Pallavi Prasad, Department of Nephrology and Renal Transplant Medicine, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi 110029, Delhi, India
Co-first authors: Meenakshi Rajput and Sumitra Bachani.
Author contributions: Rajput M and Kumar A conceptualized and coordinated the writing of the paper; Bachani S, Suri J, and Bharti R contributed to the literature review and refined the content; Kumar R, Verma H, and Prasad P provided critical insights on nephrology and made final revisions; all authors reviewed and approved the final manuscript.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest related to this manuscript.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Adarsh Kumar, DM, MD, Associate Professor, Department of Nephrology and Renal Transplant Medicine, Vardhman Mahavir Medical College and Safdarjung Hospital, Ansari Nagar East, Near AIIMS Metro Station, New Delhi 110029, Delhi, India. adarshnephro081@gmail.com
Received: June 9, 2025 Revised: July 15, 2025 Accepted: October 24, 2025 Published online: December 25, 2025 Processing time: 199 Days and 23.6 Hours
Core Tip
Core Tip: Acute kidney injury (AKI) associated with acute fatty liver of pregnancy (AFLP) occurs more frequently than AKI related to preeclampsia or hemolysis, elevated liver enzymes, and low platelets syndrome; however, it is generally non-oliguric and of relatively low severity. In some cases, kidney function may not fully recover after delivery and could require dialysis. Rarely, AFLP can manifest in the postpartum period, which presents a diagnostic challenge due to lack of prodromal symptoms and occurrence of severe AKI. AKI is key characteristic of AFLP and is included in both its diagnostic and prognostic criteria. Therapeutic plasma exchange may be considered in patients with persistent hepatic or renal dysfunction following delivery. Given that rapid recognition and prompt delivery are crucial for managing AFLP, there is a need for biomarkers, similar to the soluble fms-like tyrosine kinase-1/placental growth factor (sFlt-1/PlGF) ratio used in preeclampsia, that can facilitate earlier diagnosis and treatment.
