Copyright
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Nephrol. Dec 25, 2025; 14(4): 103649
Published online Dec 25, 2025. doi: 10.5527/wjn.v14.i4.103649
Published online Dec 25, 2025. doi: 10.5527/wjn.v14.i4.103649
Predictive value of biomarkers for tubulointerstitial and glomerular interactions in diabetic nephropathy
Mario Alamilla-Sanchez, Martin B Yama Estrella, Enrique F Morales López, Daniel Delgado Pineda, Department of Nephrology, November 20 National Medical Center, Mexico City 03104, Colonia del Valle, Mexico
Author contributions: Alamilla-Sanchez M designed the overall concept and outline of the manuscript; Alamilla-Sanchez M, Yama Estrella MB, Morales López EF, and Delgado Pineda D contributed to the discussion and design of the manuscript, the writing and editing of the manuscript, illustrations, and review of the literature; and all authors thoroughly reviewed and endorsed the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mario Alamilla-Sanchez, MD, Associate Professor, Department of Nephrology, November 20 National Medical Center, Félix Cuevas 540, Mexico City 03104, Colonia del Valle, Mexico. silenoz1@hotmail.com
Received: November 26, 2024
Revised: March 23, 2025
Accepted: April 11, 2025
Published online: December 25, 2025
Processing time: 392 Days and 11.9 Hours
Revised: March 23, 2025
Accepted: April 11, 2025
Published online: December 25, 2025
Processing time: 392 Days and 11.9 Hours
Core Tip
Core Tip: Diabetic kidney disease is characterized by albuminuria and progressive deterioration of renal function; however, traditional markers may fail to categorize a substantial proportion of patients who do not exhibit albuminuria. Tubulointerstitial biomarkers have been proven to be particularly valuable in predicting the onset of albuminuria and the progression of kidney injury in patients with type 2 diabetes. The standardization of biomarker measurements, including neutrophil gelatinase-associated lipocalin, kidney injury molecule-1, and periostin, can potentially enhance prognostic indicators for diabetic kidney disease.