Gembillo G, Peritore L, Spadaro G, Cuzzola F, Calderone M, Messina R, Di Piazza S, Sudano F, Gambuzza ME, Princiotto M, Soraci L, Santoro D. Kidney involvement and anemia in COVID-19 infection. World J Nephrol 2025; 14(3): 107582 [DOI: 10.5527/wjn.v14.i3.107582]
Corresponding Author of This Article
Guido Gembillo, Unit of Nephrology and Dialysis, AOU "G. Martino", University of Messina, Via Consolare Valeria n 1, Messina 98125, Sicilia, Italy. ggembillo@gmail.com
Research Domain of This Article
Urology & Nephrology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Nephrol. Sep 25, 2025; 14(3): 107582 Published online Sep 25, 2025. doi: 10.5527/wjn.v14.i3.107582
Kidney involvement and anemia in COVID-19 infection
Guido Gembillo, Luigi Peritore, Giuseppe Spadaro, Felicia Cuzzola, Michela Calderone, Rossella Messina, Simona Di Piazza, Flavia Sudano, Maria Elsa Gambuzza, Maria Princiotto, Luca Soraci, Domenico Santoro
Guido Gembillo, Luigi Peritore, Giuseppe Spadaro, Felicia Cuzzola, Michela Calderone, Rossella Messina, Simona Di Piazza, Flavia Sudano, Domenico Santoro, Unit of Nephrology and Dialysis, AOU "G. Martino", University of Messina, Messina 98125, Sicilia, Italy
Maria Elsa Gambuzza, Territorial Office of Messina, Ministry of Health, Messina 98125, Sicilia, Italy
Maria Princiotto, Luca Soraci, Unit of Geriatric Medicine, Italian National Research Center on Aging (IRCCS INRCA), Cosenza 87100, Calabria, Italy
Co-corresponding authors: Guido Gembillo and Luca Soraci.
Author contributions: Gembillo G, Peritore L, Santoro D, and Soraci L contributed to the literature search; Gembillo G, Santoro D, Spadaro G, and Cuzzola F contributed to conceptualization; Calderone M, Messina R, Di Piazza S, Gambuzza ME, and Princiotto M contributed to study selection; Gembillo G, Peritore L, Soraci L, and Sudano F contributed to manuscript drafting; both Gembillo G and Soraci L played indispensable roles in the experimental design, data interpretation and manuscript preparation as the co-corresponding authors; all authors have read and agreed to the published version of the manuscript.
Conflict-of-interest statement: We have no conflict of interest.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Guido Gembillo, Unit of Nephrology and Dialysis, AOU "G. Martino", University of Messina, Via Consolare Valeria n 1, Messina 98125, Sicilia, Italy. ggembillo@gmail.com
Received: March 26, 2025 Revised: May 7, 2025 Accepted: July 24, 2025 Published online: September 25, 2025 Processing time: 175 Days and 10.5 Hours
Core Tip
Core Tip: Severe acute respiratory syndrome coronavirus 2, the causative agent of coronavirus disease 2019 (COVID-19) infection, has had a major impact worldwide. People with chronic kidney disease (CKD) and COVID-19 have an increased risk of mortality and hospitalization, with anemia, which is common in CKD, exacerbating outcomes. Patients with CKD show resistance to erythropoietin (EPO)-stimulating agents and require higher doses even after infection. Anemia in CKD is exacerbated by factors such as decreased EPO production, red blood cell fragmentation, iron or folic acid deficiency, platelet dysfunction and excessive hepcidin synthesis. These factors contribute to poor iron regulation, which further complicates anemia in COVID-19 patients.
