Systematic Reviews
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Nephrol. Mar 25, 2025; 14(1): 97373
Published online Mar 25, 2025. doi: 10.5527/wjn.v14.i1.97373
Effect of kidney transplantation on sexual dysfunction in patients with end stage renal disease: A systematic review
Jaydeep Jain, Mahendra Singh, Shashank Kumar, Om Kumar Yadav, Ankit Shettar, Shiv Charan Navriya, Deepak Prakash Bhirud, Gautam Ram Choudhary, Arjun Singh Sandhu
Jaydeep Jain, Mahendra Singh, Shashank Kumar, Om Kumar Yadav, Ankit Shettar, Shiv Charan Navriya, Deepak Prakash Bhirud, Gautam Ram Choudhary, Arjun Singh Sandhu, Department of Urology, All India Institute of Medical Sciences, Jodhpur 342008, Rājasthān, India
Author contributions: Jain J participated in the initial and final literature searches, conducted data analysis, and wrote the manuscript; Singh M provided suggestions for refining the search strategy, conducted data analysis, and wrote and edited the manuscript; Kumar S conducted the search and contributed to writing the manuscript; Shettar A and Yadav OK performed the searches; Navriya SC and Bhirud DP resolved disagreements, edited the manuscript, and assisted in the quality assessment of studies; Choudhary GR and Sandhu AS edited the final manuscript and provided guidance during the preparation of the initial manuscript.
Conflict-of-interest statement: The authors deny any conflict of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mahendra Singh, DNB, Associate Professor, Department of Urology, All India Institute of Medical Sciences, Basni Industrial Area, Jodhpur 342008, Rājasthān, India. dr.mahi1118@gmail.com
Received: May 28, 2024
Revised: September 17, 2024
Accepted: October 28, 2024
Published online: March 25, 2025
Processing time: 236 Days and 13.5 Hours
Core Tip

Core Tip: Kidney transplantation (KTx) may offer improvements in erectile function (EF) for males with end-stage renal disease, though the overall evidence is inconclusive. This systematic review and meta-analysis found a small, non-significant improvement in EF post-transplantation, with high variability between studies. Living-donor transplant recipients may experience greater EF benefits than deceased-donor recipients. While KTx has the potential to improve sexual function, adjunct therapies like phosphodiesterase type 5 inhibitors may be necessary for persistent erectile dysfunction. Future research should focus on larger, well-designed studies to clarify KTx’s impact on sexual health.