Transition from acute kidney injury to chronic kidney disease in liver cirrhosis patients: Current perspective

Core Tip

Core Tip: In liver cirrhosis patients, acute kidney injury (AKI) frequently progresses to chronic kidney disease (CKD) through an intermediary stage known as acute kidney disease. This progression is driven by maladaptive repair processes, such as tubular cell cycle arrest and fibrosis, and exacerbated by cirrhosis-related hemodynamic and neurohormonal changes. Early detection of this AKI-to-CKD transition is crucial, and novel biomarkers and innovative imaging techniques, such as renal elastography, may present promising avenues for risk assessment and diagnosis. Integrating these tools into clinical practice, alongside targeted antifibrotic therapies and oxidative stress modulation, presents a promising strategy for managing renal complications in cirrhosis patients.