Evidence Review
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Nephrol. Mar 25, 2025; 14(1): 101576
Published online Mar 25, 2025. doi: 10.5527/wjn.v14.i1.101576
Intravenous iron in chronic kidney disease without anaemia but iron deficiency: A scoping review
Abdulrahman Alsunaid, Sebastian Spencer, Sunil Bhandari
Abdulrahman Alsunaid, Sebastian Spencer, Sunil Bhandari, Department of Medical Science, Hull York Medical School, Kingston Upon Hull HU6 7RU, United Kingdom
Sebastian Spencer, Department of Medical Science, University of Hull, Kingston Upon Hull HU6 7RU, United Kingdom
Sebastian Spencer, Sunil Bhandari, Department of Academic Renal, Hull University Teaching Hospitals NHS Trust, Kingston Upon Hull HU3 2JZ, United Kingdom
Author contributions: Alsunaid A performed database searches and majority of writing; Spencer S provided concept, guidance, writing and submission; Bhandari S provided oversight and final editing.
Conflict-of-interest statement: Bhandari S was a previous trustee for KRUK, and has received honorarium from Vifor CSL, Pharmacosmos, GSK and Astellas for lectures. Alsunaid A, and Spencer S have no conflicts to declare.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sebastian Spencer, MBBS, Academic Fellow, Doctor, Department of Medical Science, University of Hull, Allam Medical Building, Bain, Hull, Kingston Upon Hull HU6 7RU, United Kingdom. sebastian.spencer2@nhs.net
Received: September 19, 2024
Revised: December 30, 2024
Accepted: January 9, 2025
Published online: March 25, 2025
Processing time: 122 Days and 22.5 Hours
Core Tip

Core Tip: Intravenous iron therapy can effectively address iron deficiency in individuals with chronic kidney disease who are non-dialysis-dependent and not anaemic, particularly when oral iron is insufficient. This review highlights the pathophysiology of iron deficiency in chronic kidney disease, the advantages of newer intravenous iron formulations, and the potential benefit of treatment in managing symptoms like restless legs syndrome. However, evidence on improvements in physical function remain uncertain, and more research is needed to refine treatment protocols.