Unleashing the pathological role of epithelial-to-mesenchymal transition in diabetic nephropathy: The intricate connection with multifaceted mechanism

doi:10.5527/wjn.v13.i2.95410

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Jun 25, 2024 (publication date) through Jan 19, 2025

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World Journal of Nephrology

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2220-6124

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Nephrol. Jun 25, 2024; 13(2): 95410
Published online Jun 25, 2024. doi: 10.5527/wjn.v13.i2.95410

Unleashing the pathological role of epithelial-to-mesenchymal transition in diabetic nephropathy: The intricate connection with multifaceted mechanism

Pitchai Balakumar

Pitchai Balakumar, The Office of Research and Development, Periyar Maniammai Institute of Science & Technology (Deemed to be University), Thanjavur 613403, Tamil Nadu, India

Pitchai Balakumar, School of Pharmacy, Faculty of Health and Medical Sciences, Taylor’s University, Subang Jaya 47600, Selangor, Malaysia

Author contributions: Balakumar P collected the literature, conceptualized the study, critically analyzed the literature, wrote the first draft and finalized the manuscript.

Conflict-of-interest statement: The author declares that no competing interests exist.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Pitchai Balakumar, PhD, Professor, Director, The Office of Research and Development, Periyar Maniammai Institute of Science & Technology (Deemed to be University), Vallam, Thanjavur 613403, Tamil Nadu, India. pbalakumar2022@gmail.com

Received: April 9, 2024
Revised: May 17, 2024
Accepted: May 30, 2024
Published online: June 25, 2024
Processing time: 76 Days and 15.9 Hours

Core Tip

Core Tip: Measures to maintain epithelial integrity and prevent epithelial-to-mesenchymal transition (EMT) are being investigated as prospective therapeutic options for diabetic nephropathy. Understanding the role of EMT in diabetic nephropathy lays the door for potential therapeutic approaches. The use of transforming growth factor-β inhibitors, renal anti-inflammatory agents, antifibrotics, and antioxidants to target EMT-related pathways and renal fibrosis may have the potential to reduce the evolution of diabetic nephropathy and to prevent kidney damage.