Gadelkareem RA, Abdelgawad AM, Reda A, Azoz NM, Zarzour MA, Mohammed N, Hammouda HM, Khalil M. Preemptive living donor kidney transplantation: Access, fate, and review of the status in Egypt. World J Nephrol 2023; 12(3): 40-55 [PMID: 37476008 DOI: 10.5527/wjn.v12.i3.40]
Corresponding Author of This Article
Rabea Ahmed Gadelkareem, MD, Assistant Professor, Department of Urology, Assiut Urology and Nephrology Hospital, Faculty of Medicine, Assiut University, Elgamaa Street, Assiut 71515, Egypt. rabeagad@aun.edu.eg
Research Domain of This Article
Transplantation
Article-Type of This Article
Retrospective Cohort Study
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Gadelkareem RA, Abdelgawad AM, Reda A, Azoz NM, Zarzour MA, Mohammed N, Hammouda HM, Khalil M. Preemptive living donor kidney transplantation: Access, fate, and review of the status in Egypt. World J Nephrol 2023; 12(3): 40-55 [PMID: 37476008 DOI: 10.5527/wjn.v12.i3.40]
World J Nephrol. May 25, 2023; 12(3): 40-55 Published online May 25, 2023. doi: 10.5527/wjn.v12.i3.40
Preemptive living donor kidney transplantation: Access, fate, and review of the status in Egypt
Rabea Ahmed Gadelkareem, Amr Mostafa Abdelgawad, Ahmed Reda, Nashwa Mostafa Azoz, Mohammed Ali Zarzour, Nasreldin Mohammed, Hisham Mokhtar Hammouda, Mahmoud Khalil
Rabea Ahmed Gadelkareem, Amr Mostafa Abdelgawad, Ahmed Reda, Mohammed Ali Zarzour, Nasreldin Mohammed, Hisham Mokhtar Hammouda, Mahmoud Khalil, Department of Urology, Assiut Urology and Nephrology Hospital, Faculty of Medicine, Assiut University, Assiut 71515, Egypt
Nashwa Mostafa Azoz, Department of Internal Medicine, Assiut University Hospital, Faculty of Medicine, Assiut University, Assiut 71515, Egypt
Author contributions: Gadelkareem RA, Abdelgawad AM, and Zarzour MA designed the research, collected the data, and wrote the paper; Reda A, Azoz NM, and Mohammed N contributed to the statistical analysis, literature review, writing and revision; Hammouda HM and Khalil M contributed to the literature review, writing, revision and supervision of the work; All authors approved the paper.
Institutional review board statement: This study has been approved in 2017 by the Medical Ethics Committee of the Faculty of Medicine, Assiut University, Egypt as a topic in a research project titled "Outcome of living donor kidney transplantation in Assiut Urology and Nephrology Hospital". The institutional review board number is 17200148.
Informed consent statement: This article is a retrospective study. Patients were not required to give informed consent to the study because the manipulated data were anonymous and were obtained after each patient agreed to treatment by consent.
Conflict-of-interest statement: The authors have no financial relationships to disclose.
Data sharing statement: The data supporting this study are available from the corresponding author on reasonable request.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Corresponding author: Rabea Ahmed Gadelkareem, MD, Assistant Professor, Department of Urology, Assiut Urology and Nephrology Hospital, Faculty of Medicine, Assiut University, Elgamaa Street, Assiut 71515, Egypt. rabeagad@aun.edu.eg
Received: January 11, 2023 Peer-review started: January 11, 2023 First decision: February 2, 2023 Revised: February 22, 2023 Accepted: March 14, 2023 Article in press: March 14, 2023 Published online: May 25, 2023 Processing time: 121 Days and 16.2 Hours
Core Tip
Core Tip: Patients with preemptive access to kidney transplantation (PAKT) may have significant differences from those with conventional access to KT, warranting more evaluation. In this study, known primary kidney disease was an independent factor of achievement of living donor KT (LDKT). In addition, the older age and female sex were independent predictors of non-achievement of LDKT. However, unavailability, regression, and exclusion of LDs and patient regression on starting dialysis may prevent achievement of preemptive LDKT (PLDKT) in patients with PAKT. Despite its non-significant effect, PAKT may improve the low rates of PLDKT. The current literature review may refer to that PLDKT has comparable or variably better outcomes than the conventional LDKT. Hence, PLDKT is recommended as the first choice for each candidate patient. In Egypt, the rate of PLDKT is still lower than that of other countries, warranting implementation of effective strategies to promote PLDKT.
