Prediction of mortality among patients with chronic kidney disease: A systematic review

doi:10.5527/wjn.v10.i4.59

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World Journal of Nephrology

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Systematic Reviews

World J Nephrol. Jul 25, 2021; 10(4): 59-75
Published online Jul 25, 2021. doi: 10.5527/wjn.v10.i4.59

Prediction of mortality among patients with chronic kidney disease: A systematic review

Panupong Hansrivijit, Yi-Ju Chen, Kriti Lnu, Angkawipa Trongtorsak, Max M Puthenpura, Charat Thongprayoon, Tarun Bathini, Michael A Mao, Wisit Cheungpasitporn

Panupong Hansrivijit, Yi-Ju Chen, Kriti Lnu, Department of Internal Medicine, UPMC Pinnacle, Harrisburg, PA 17104, United States

Angkawipa Trongtorsak, Department of Internal Medicine, Amita Health Saint Francis Hospital, Evanston, IL 60202, United States

Max M Puthenpura, Department of Medicine, Drexel University College of Medicine, Philadelphia, PA 19129, United States

Charat Thongprayoon, Wisit Cheungpasitporn, Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, MN 55905, United States

Tarun Bathini, Department of Internal Medicine, University of Arizona, Tucson, AZ 85721, United States

Michael A Mao, Division of Nephrology and Hypertension, Mayo Clinic, Jacksonville, FL 32224, United States

Author contributions: Hansrivijit P contributed to acquisition of data, analysis, and interpretation of data, drafting the article, and final approval; Chen YJ, Lnu K and Trongtorsak A contributed to acquisition of data, analysis of data, and drafting the article; Puthenpura MM contributed to acquisition of data and drafting the article; Thongprayoon C and Bathini T contributed to acquisition of data and final approval; Mao MA and Cheungpasitporn W contributed to interpretation of data, revising the article, and final approval.

Conflict-of-interest statement: The authors have declared no potential conflicts of interest.

PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.

Corresponding author: Wisit Cheungpasitporn, FACP, FASN, FAST, Associate Professor, Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, United States. wcheungpasitporn@gmail.com

Received: March 21, 2021
Peer-review started: March 21, 2021
First decision: May 6, 2021
Revised: May 11, 2021
Accepted: July 23, 2021
Article in press: July 23, 2021
Published online: July 25, 2021
Processing time: 137 Days and 14.4 Hours

Core Tip

Core Tip: Although the current evidence has shown that several clinical factors are associated with mortality in chronic kidney disease (CKD), the accuracy of mortality prediction has not been clearly demonstrated. Our systematic review of studies that reported prognostic mortality factors using area under the receiver operating characteristic curve analysis in CKD patients provides an accuracy measurement. A total of 18 studies were identified. Eight hundred thirty two patients had non-dialysis CKD, and 13747 patients had end-stage kidney disease. Of 24 predictive factors, none were considered outstanding for mortality prediction. A total of seven predictive factors were identified as excellent. Our review summarizes the current accuracy of prognostic factors for CKD mortality.