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Editorial
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Nephrol. Sep 25, 2025; 14(3): 107955
Published online Sep 25, 2025. doi: 10.5527/wjn.v14.i3.107955
Diagnostic challenges and treatment approaches for hydatid cysts in atypical localizations
Konstantin Semash, Mikhail Voskanov
Konstantin Semash, Department of Minimally Invasive Pediatric Surgery and Transplantation, National Children's Medical Center, Tashkent 100171, Uzbekistan
Mikhail Voskanov, Department of Emergency Medicine, Mayo Clinic, Rochester, MN 55905, United States
Author contributions: Semash K, Voskanov M was responsible for the conception, writing, critical content development, and final approval of this editorial manuscript.
Conflict-of-interest statement: The author declares no actual or potential conflicts of interest.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Konstantin Semash, MD, PhD, Department of Minimally Invasive Pediatric Surgery and Transplantation, National Children's Medical Center, Parkent Street 294, Tashkent 100171, Uzbekistan. doctorsemash@gmail.com
Received: April 2, 2025
Revised: April 22, 2025
Accepted: June 23, 2025
Published online: September 25, 2025
Processing time: 169 Days and 14.1 Hours
Abstract

Hydatid disease, caused by the Echinococcus granulosus parasite, is traditionally associated with liver and lung involvement. However, recent years have seen an increase in cases with atypical localizations, such as the kidneys, thyroid, soft tissues, and bones. The study by Celik et al presents a series of five clinical cases where hydatid cysts were found in these rare anatomical regions, challenging conventional diagnostic and therapeutic approaches. The paper emphasizes the importance of differential diagnosis, as these cases can mimic other conditions, such as cancer, abscesses, or cysts. Advanced imaging techniques, such as computed tomography, magnetic resonance imaging, and ultrasound, play a crucial role in accurate diagnosis and help avoid misdiagnosis. The study demonstrates that early diagnosis and appropriate treatment of echinococosis in atypical localizations are critical for preventing complications like cyst rupture and secondary infections. The use of albendazole and surgical intervention, especially in combination with modern imaging techniques, yields good outcomes in these patients. However, several unanswered questions remain: What are the precise criteria for selecting the optimal treatment method in each case? What is the long-term effectiveness of different approaches? Do patients with hydatid cysts in atypical locations require additional monitoring and preventive treatment to avoid recurrence? Addressing these questions requires further research, and a multidisciplinary approach involving radiologists, surgeons, and infectious disease specialists is essential to optimize diagnosis and treatment. Early and accurate diagnostic methods based on differential diagnosis play a key role in improving treatment outcomes and reducing morbidity.

Keywords: Echinococcosis; Echinococcosis granulosus; Hydatid disease; Atypical localization; Diagnosis; Surgery; Imaging; Multidisciplinary management

Core Tip: Hydatid disease in atypical anatomical sites presents significant diagnostic and therapeutic challenges due to its rarity and variable clinical manifestations. This editorial summarizes the current evidence on cystic echinococcosis in unusual localizations, emphasizing imaging strategies, surgical management, and the limitations of serological testing. The paper also critiques a recent case series by Celik et al, underlining the importance of multidisciplinary care and standardized reporting in these complex scenarios.