Hamarat H. Glomerular filtration rate and comorbidity factors in elderly hospitalizations. World J Nephrol 2025; 14(1): 98837 [DOI: 10.5527/wjn.v14.i1.98837]
Corresponding Author of This Article
Hatice Hamarat, MD, Department of Internal Medicine, Eskişehir City Hospital, 71 Evler Mahallesi, Çavdarlar Sokak, Eskişehir 26080, Türkiye.hklncal@hotmail.com
Research Domain of This Article
Geriatrics & Gerontology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Nephrol. Mar 25, 2025; 14(1): 98837 Published online Mar 25, 2025. doi: 10.5527/wjn.v14.i1.98837
Glomerular filtration rate and comorbidity factors in elderly hospitalizations
Hatice Hamarat
Hatice Hamarat, Department of Internal Medicine, Eskişehir City Hospital, Eskişehir 26080, Türkiye
Author contributions: Hamarat H contributed solely to the article.
Institutional review board statement: The study received approval from the relevant Institutional Review Board based on decision E-25403353-050.99-2020 and assigned number 307.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The data belong to a hospital and cannot be shared.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hatice Hamarat, MD, Department of Internal Medicine, Eskişehir City Hospital, 71 Evler Mahallesi, Çavdarlar Sokak, Eskişehir 26080, Türkiye.hklncal@hotmail.com
Received: July 7, 2024 Revised: October 16, 2024 Accepted: December 12, 2024 Published online: March 25, 2025 Processing time: 196 Days and 23.2 Hours
Abstract
BACKGROUND
With an increase in the elderly population, the frequency of hospitalizations in recent years has also risen at a rapid pace. This, in turn, has resulted in poor outcomes and costly treatments. Hospitalization rates increase in elderly patients due to a decline in glomerular filtration rate (GFR).
AIM
To investigate the connection between GFR and comorbidity and reasons for hospitalization in elderly patients.
METHODS
We analyzed patients aged 75 years and over who were admitted to the internal medicine clinic of a tertiary hospital in Eskisehir. At admission, we calculated GFR values using the Modification of Diet in Renal Disease study formula and classified them into six categories: G1, G2, G3a, G3b, G4, and G5. We analyzed associations with hospitalization diagnoses and comorbidity factors.
RESULTS
The average age of the patients was 80.8 years (± 4.5 years). GFR was 57.287 ± 29.5 mL/kg/1.73 m2 in women and 61.3 ± 31.5 mL/kg/1.73 m2 in men (P = 0.106). Most patients were admitted to the hospital at G2 stage (32.8%). The main reasons for hospitalization were anemia (34.4% and 28.6%) and malnutrition (20.9% and 20.8%) in women and men, respectively (P = 0.078). The most frequent comorbidity leading to hospitalization was arterial hypertension (n = 168, 28%), followed by diabetes (n = 166, 27.7%) (P = 0.001).
CONCLUSION
When evaluating geriatric patients, low GFR alone does not provide sufficient information. Patients’ comorbid factors should also be taken into account. There is no association between low GFR during hospitalization and hospitalization-related diagnoses. Knowing the GFR value before hospitalization will be more informative in such studies.
Core Tip: The process of aging is a natural phenomenon, and the quality of life is of paramount importance during this period. The objective of this study was to examine the relationship between renal filtration rate and health outcomes, as well as the incidence of hospitalization, in elderly patients. The analysis was conducted in patients aged 75 years and older who were admitted to the internal medicine clinic of a tertiary care hospital in Eskisehir. At the time of admission, renal filtration rates were calculated using the Modification of Diet in Renal Disease formula and classified into six categories. Associations with health problems during the course of hospitalization were analyzed.
