Neurological manifestations of Zika virus infection

Table 1 Clinical features of Zika virus disease

Mild symptoms	Other complications of the disease
Fever	Guillain-Barré syndrome
Rash	Microcephaly in fetuses and newborns
Joint pain
Conjunctivitis
Muscle pain
Headache

Table 2 Zika virus disease interim case definitions according to World Health Organization

Suspected case	Probable case	Confirmed case
A person presenting with rash and/or fever and at least one of the following signs or symptoms: Arthralgia, or Arthritis, or Conjunctivitis (non-purulent/ hyperaemic)	A suspected case with presence of: IgM antibody against Zika virus (with no evidence of infection with other flaviviruses) and An epidemiological link (contact with a confirmed case, or a history of residing in or travelling to an area with local transmission of Zika virus within 2 wk prior to onset of symptoms)	A person with laboratory confirmation of recent Zika virus infection: Presence of Zika virus RNA or antigen in serum or other samples, or IgM antibody against Zika virus positive and PRNT90 for Zika virus with titre ≥ 20 and Zika virus PRNT90 titre ratio ≥ 4 compared to other tested flaviviruses, and Exclusion of other flaviviruses

Available from: URL: http://www.who.int/csr/disease/zika/case-definition/en.

Table 3 Preventive measures

Vector control measures	Personal preventive measures
Removal of sources of standing water	Avoidance of mosquito exposure Insecticide application
Implementation of accurate mosquito control programs	Prevention of sexual transmission by use of preventive measures Travelling avoidance to risk countries during pregnancy