Review
Copyright ©The Author(s) 2015.
World J Virology. Feb 12, 2015; 4(1): 1-12
Published online Feb 12, 2015. doi: 10.5501/wjv.v4.i1.1
Table 1 Sustained virological response rate in human immunodeficiency virus/hepatitis C virus coinfected patients naïve for anti-hepatitis C virus treatment
Ref.SVR rate in therapy-naive patients
Genotype 1Genotype 2Genotype 3Genotype 4
Peg-IFN plus ribavirin[85]35.6% in 191 patients72.4% in 152 patients32.6% in 46 patients
Peg-IFN plus ribavirin + boceprevir[32]60.7% in 61 patients---
Peg-IFN plus ribavirin + telaprevir[51]74% in 38 patients---
Peg-IFN plus ribavirin + sofosbuvir[44]91% in 23 patients
Peg-IFN plus ribavirin + simeprevir[55]79.2% in 52 patients---
Peg-IFN plus ribavirin + faldaprevir[59]73.7% in 227 patients1---
Sofosbuvir plus ribavirin[60]76% in 114 patients288% in 26 patients367% in 42 patients3-
Sofosbuvir plus ribavirin[62]84% in 112 patients90% in 19 patients91% in 57 patients84% in 31 patients
Sofosbuvir plus ledipasvir[63]100% in 13 patients---
Paritaprevir-r/ombitasvir + dasabuvir + ribavirin[65]93.50% in 31 patients---
Table 2 Anti-human immunodeficiency virus drugs contraindicated during anti-hepatitis C virus treatment
Contraindicated anti-HIV drugs
NRTINNRTIIPINICCR5 antagonist
Alpha interferon-----
RibavirinDidanosine, stavudine, zidovudine----
BoceprevirDidanosine, stavudine, zidovudineEfavirenzLopinavir/r, atazanavir/r, darunavir/rEVG/cobi/TDF/FTC1Maraviroc3
TelaprevirDidanosine, stavudine, zidovudineEfavirenz2Lopinavir/r darunavir/r fosamprenavir/r-Maraviroc3
SofosbuvirDidanosine, stavudine, zidovudine-Tipranavir/rNo data-
SimeprevirDidanosine, stavudine, zidovudineEfavirenz, delavirdine etravirine, nevirapineAll protease inhibitors with or without ritonavir boosterEVG/cobi/TDF/FTCNo data
DaclatasvirDidanosine, stavudine, zidovudineEfavirenz4, nevirapine, etravirineLopinavir/r1 darunavir/r1 fosamprenavir/r1 tipranavir/r--
LedipasvirDidanosine, stavudine, zidovudineNevirapine1, etravirine1Lopinavir/r1 fosamprenavir/r1 tipranavir/rEVG/cobi/TDF/FTC1No data
Dasabuvir/ ombitasvir/ paritaprevir-rDidanosine, stavudine, zidovudineEfavirenz, rilpivirine nevirapine1 etravirine1lopinavir/r1 fosamprenavir/r tipranavir/r1EVG/cobi/TDF/FTC1No data