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©2013 Baishideng.
World J Virol. May 12, 2013; 2(2): 79-90
Published online May 12, 2013. doi: 10.5501/wjv.v2.i2.79
Published online May 12, 2013. doi: 10.5501/wjv.v2.i2.79
Virus | Protein | Interaction with SUMO | Proposed impact on viral or cellular activity | Ref. |
Chicken embryo lethal orphan Adenovirus | Gam1 | Overall SUMOylation decrease through SAE1/2 degradation and reduced Ubc9 expression | Cellular transcriptional activation | [49,50] |
PML-NBs dispersion | [51] | |||
Interference with HDAC1 SUMOylation | Cellular transcriptional activation | [51] | ||
Geminivirus | AL1 | Promotes SUMOylation of selected host factors | Viral replication | [57,58] |
Adenovirus | E1B-55K | E3 ligase SUMO-1 specific | Regulator of cell cycle and apoptosis | [59,60] |
SUMOylated | Cellular transformation | [63] | ||
Interaction with PML-NBs | [62,64] | |||
Kaposi’s sarcoma-associated herpesvirus | K-bZip | E3 ligase SUMO-2/3 specific | Regulator of cell cycle and apoptosis | [66] |
SUMOylated | Cellular transcriptional repression | [65,66] | ||
K-Rta | E3 ubiquitin ligase activity against SUMOylated proteins | PML-NBs dispersion | [119] | |
Vaccinia | E3 | SUMOylated | Regulator of apoptosis | [69] |
A40R | SUMOylated | Viral replication | [74] | |
Bovine papillomavirus | E1 | SUMOylated | Viral replication | [71,72] |
Human papillomavirus | L2 | SUMOylated | Viral capsid assembly | [93] |
Increase in cellular SUMO 2/3 conjugation | [93] | |||
Moloney murine leukemia | CA | SUMOylated | Viral replication | [75] |
Influenza A | NS1 | SUMOylated | Viral replication | [78] |
Cytomegalovirus | IE1 | SUMOylated | Viral replication | [80,81] |
Interaction with selected host factors | PML dispersion | [123] | ||
SUMOylated | ||||
IE2 | Interaction with SUMOylated proteins | Viral replication | [82] | |
SUMOylated | Viral replication | [83] | ||
UL44 | Interaction with Ubc9 | Viral replication | [84] | |
Epstein-Barr | BZLF1 | SUMOylated | Reactivation of latent infections | [85,86,88] |
Rta | SUMOylated | Reactivation of latent infections | [89] | |
BGLF4 | Interaction with SUMOylated proteins | Viral replication and reactivation of latent infections | [91] | |
PML-NBs dispersion | ||||
Hantaan | NP | Interaction with Ubc9 and SUMO-1 | Virus assembly | [95,96] |
Mason-Pfizer; human immunodeficiency | Gag | Interaction with Ubc9 | Virus assembly | [97] |
[98-100] | ||||
Influenza A | M1 | SUMOylated | Virus assembly | [102,103] |
Ebola Zaire | VP35 | Promotes SUMOylation of selected host factors | IFN inhibition | [109,111] |
Herpes simplex type-1 | ICP0 | E3 ubiquitin ligase activity against SUMOylated proteins | PML-NBs dispersion | [115-117] |
Varicella zoster | ORF61 | Interaction with SUMOylated proteins | PML-NBs dispersion | [120,121] |
Encephalomyocarditis | 3C | Interaction with selected host factors | PML degradation | [122] |
- Citation: Mattoscio D, Segré CV, Chiocca S. Viral manipulation of cellular protein conjugation pathways: The SUMO lesson. World J Virol 2013; 2(2): 79-90
- URL: https://www.wjgnet.com/2220-3249/full/v2/i2/79.htm
- DOI: https://dx.doi.org/10.5501/wjv.v2.i2.79