Viral proteins and Src family kinases: Mechanisms of pathogenicity from a “liaison dangereuse”

Table 1 List of the viral proteins described in this review

Protein	Virus	Src family kinase	Phosphorylation sites (tyrosines)
Polyoma middle-T antigen	Polyomavirus	Src and Fyn	Y250, Y315 and Y322
Tyrosine kinase interacting protein	Herpesvirus saimiri	Lck	Y114 and Y127
Tegument protein VP11/12	Herpes simplex virus	Lck	Y not identified
Accessory viral protein X	Human immunodeficiency viruses and Simian immunodeficiency viruses	Fyn	Y66, Y69 and Y71
Latent membrane protein 2A	Epstein-Barr virus	Lyn	Y74 and Y85
Non-structural protein 5A	Hepatitis C virus	Src	Y not identified
Accessory protein Nef	Human immunodeficiency viruse-1	SFKs	None
Non-structural 1	Avian influenza virus	Src	None
Accessory protein p13	Human T-cell leukemia virus type 1	SFKs	None
RNA-dependent RNA polymerase non-structural protein 5B	Hepatitis C virus	Src	None

SFKs: Src family kinases; VP: Viral protein.