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World J Virol. Jun 25, 2023; 12(3): 193-203
Published online Jun 25, 2023. doi: 10.5501/wjv.v12.i3.193
Table 1 Case definition criteria for multisystemic inflammatory syndrome in children issued by the Royal College of Pediatrics and Child Health, World Health Organization and Centers for Disease Control and Prevention
Criteria
RCPCH[71]
WHO[72]
CDC[73]
AgeND< 21< 19
ClinicalPersistent fever > 38.5 °C. Evidence of single or multi-organ dysfunction with additional features1Fever ≥ 3 d; two of the following: (1) Mucocutaneous inflammation signs; (2) Hypotension or shock; (3) Cardiac issues2; (4) Evidence of coagulopathy; and (5) Acute gastrointestinal problemsFever ≥ 38.0 °C for ≥ 24 h; multisystemic disease involving multiple (≥ 2) organs (cardiac, renal, respiratory, hematologic, gastrointestinal, dermatologic, or neurological). Requirement of hospitalization
Inflammatory markersNeutrophilia, elevated CRP and lymphopeniaElevated markers (such as ESR, CRP or procalcitonin)Elevated CRP, ESR, fibrinogen, procalcitonin, d-dimer, ferritin, neutrophils, LDH, or IL-6 or reduced albumin and/or lymphocytes
COVID-19 testPositive or negative SARS-CoV-2 RT-PCR testEvidence of COVID-19 (via RT-PCR, antigen test, or serology) or probable contact with patients contaminated with SARS-CoV-2RT-PCR, serology or antigen test positive for COVID-19 (currently or in recent period) or exposure to the virus within 4 wk prior to symptom onset
Exclusion factorsExclusion of any other microbial causeNo other obvious etiology for the inflammationAbsence of other plausible alternative diagnoses