Comparison of three pediatric studies investigating acute hepatitis of unknown etiology

Figure 1 A phylogenetic tree of the whole adeno-associated virus serotype 2 genomes, including 37 isolates from three studies (England: n = 15, Scotland: n = 9, United States: n = 13) and 97 reference strains from GenBank, was constructed via the maximum likelihood method. The reliability of the phylogenetic tree was assessed with 500 bootstrap replicates. The evolutionary distances were computed using the maximum likelihood method. These analyses were performed with the MEGA software program (version 11.0.13). Bootstrapped values less than 80 are not shown.