Leowattana W. Angiotensin-converting enzyme 2 receptors, chronic liver diseases, common medications, and clinical outcomes in coronavirus disease 2019 patients. World J Virol 2021; 10(3): 86-96 [PMID: 34079691 DOI: 10.5501/wjv.v10.i3.86]
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05631521
Submitted on:
May 27, 2021, 08:26
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Reader Comments:
It is a good explanation about how ACEi works in the liver, but this article explain about the missing ling is about the explanation the metformin as a common medication. The interesting things is post mortem examination how the microvascular steatosis and mild inflammation infiltrates in liver does meaningful for next research.
The drawback for this article are not stated that about the gender, ages, the cause of liver disease and the possibility using the drug. What kind of drug use, the interaction. The article discuss about the relationship between how the ACEi expression not in the human. Overall it is a good article to read.
Reply from the Editorial Office:
Thank you very much for your comments.
Author's Reply:
Replied on January 28, 2022, 01:58
Thank you very much for your valuable comments.
Reader's ID:
05462116
Submitted on:
May 19, 2021, 07:37
Reader Expertise:
Reader’s expertise on the topic of the manuscript
Conflicts-of-Interest Statement:
Does the reader have a conflict of interest?
Reader Comment Standards for Published Articles:
1 Title
Does the title reflect the main subject/hypothesis of the manuscript?
2 Abstract
Does the abstract summarize and reflect the work described in the manuscript?
3 Key Words
Do the key words reflect the focus of the manuscript?
4 Background
Does the manuscript adequately describe the background, present status and significance of the study?
5 Methods
Does the manuscript describe methods (e.g., experiments, data analysis, surveys, and clinical trials, etc.) in adequate detail?
6 Results
Are the research objectives achieved by the experiments used in this study?
Has the study made meaningful contributions towards research progress in this field?
7 Discussion
Does the manuscript interpret the findings adequately and appropriately, highlighting the key points concisely, clearly and logically?
Are the findings and their applicability/relevance to the literature stated in a clear and definite manner?
Is the Discussion accurate and does it discuss the paper’s scientific significance and/or relevance to clinical practice sufficiently?
8 Illustrations and Tables
Are the figures, diagrams and tables sufficient, good quality and appropriately illustrative of the paper contents?
Do figures require labeling with arrows, asterisks, etc., or better legends?
9 Biostatistics
Does the manuscript meet the requirements of biostatistics?
10 Units
Does the manuscript meet the requirements of use of SI units?
11 References
Does the manuscript appropriately cite the latest, important and authoritative references in the Introduction and Discussion sections?
Does the author self-cite, omit, incorrectly cite and/or over-cite references?
12 Quality of manuscript organization and presentation
Is the manuscript concisely and coherently organized and presented?
Are the style, language and grammar accurate and appropriate?
13 Ethics statements
For all manuscripts involving human studies and/or animal experiments, author(s) must submit the related formal ethics documents that were reviewed and approved by their local ethical review committee. Did the manuscript meet the requirements of ethics?
Scientific Quality:
The overall quality of the manuscript, based on the above-listed criteria, should be evaluated and classified according to the following five categories
Language Quality:
Language quality (style, grammar, and spelling) should be evaluated and classified according to the following five categories.
Reader Comments:
Under the special background of pandemic, the diagnosis and treatment of abdominal diseases are fraught with difficulties and challenges. Novel coronavirus infection may overlap abdominal symptoms with other abdominal inflammation, which is a wake-up call for clinicians. In particular, novel coronavirus may constitute the direct cause of cholecystitis and hepatitis, thus giving clinicians more thought. It is hoped that the diagnosis and treatment of hepatic and gall diseases by clinicians can be more accurate and the etiology can be explored, instead of just making diagnosis and treatment in this special period.
The purpose of this article is to analyze the molecular level risk of gastrointestinal organ novel coronavirus inflammation. We read with great interest of this article in your journal about the high expression of ACE-2 in the liver and gall of COVID-infected patients. In other words, it's time to think about the molecular mechanisms by which viruses infect organs. Combined with the inter-action between ACE2 and novel coronavirus, we further considered the potential pathological and molecular characteristics of novel coronavirus, and antiviral measures of digestive organs. This is particularly important as the pandemic intensifies.
Reply from the Editorial Office:
First, thank you very much for your professional comments on the article published in World Journal of Virology.
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Author's Reply:
Replied on January 28, 2022, 01:57
Thank you very much for your valuable comment and suggestion.