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1
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Bin S, Im S. Neonatal ascites, leading to the diagnosis of congenital dengue with plasma leakage. Clin Case Rep 2024; 12:e9493. [PMID: 39434766 PMCID: PMC11491758 DOI: 10.1002/ccr3.9493] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/27/2024] [Revised: 08/22/2024] [Accepted: 09/16/2024] [Indexed: 10/23/2024] Open
Abstract
Although Cambodia is a dengue-endemic country, mother-to-child transmission of dengue virus has yet to be documented. We report a rare case for congenital dengue diagnosed by RT-PCR in a 4-day-old neonate with ascites. The neonate was initially treated for suspected perinatal infection. The management was supportive.
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Affiliation(s)
- Sakviseth Bin
- Neonatal Intensive Care UnitCalmette HospitalPhnom PenhCambodia
- University of Health SciencesPhnom PenhCambodia
| | - Sethikar Im
- Neonatal Intensive Care UnitCalmette HospitalPhnom PenhCambodia
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2
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Zambrano LEA, Zevallos VMV, Soraya GV, Istifiani LA, Pamungkas SA, Ulhaq ZS. Transplacental transmission of dengue infection. World J Virol 2024; 13:91325. [PMID: 39323447 PMCID: PMC11400998 DOI: 10.5501/wjv.v13.i3.91325] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 12/27/2023] [Revised: 06/14/2024] [Accepted: 07/04/2024] [Indexed: 08/29/2024] Open
Abstract
We specifically addressed the persistent challenge of dengue in endemic regions, highlighting the potential seriousness of dengue infection through vertical transmission. Vertical dengue transmission has been well documented, particularly in hyper-endemic regions, including Ecuador. Herein, we present a neonate diagnosed with congenital dengue and review similar cases from previously published reports. Although congenital dengue is commonly infected with severe serotypes of DENV (DENV-1 and DENV-2) infections, favorable outcomes are generally observed.
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Affiliation(s)
| | - Victor Manuel Vasquez Zevallos
- Department of Medicine, Technical University of Manabi, Manabi 130101, Ecuador
- Department of Pediatrics, Verdi Cevallos Balda Hospital, Portoviejo 130105, Ecuador
| | - Gita Vita Soraya
- Department of Biochemistry, Hasanuddin University, Makassar 90245, Indonesia
| | - Lola Ayu Istifiani
- Department of Nutrition, Faculty of Health Sciences, Brawijaya University, Malang 65100, Indonesia
| | | | - Zulvikar Syambani Ulhaq
- Research Center for Preclinical and Clinical Medicine, National Research and Innovation Agency Republic of Indonesia, Cibinong 16911, Indonesia
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3
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Douglas KO, Gittens-St Hilaire M. First clinical reports of acute hantavirus and dengue infections among pregnant women in the Caribbean. Infect Dis (Lond) 2024; 56:564-574. [PMID: 38767622 DOI: 10.1080/23744235.2024.2348631] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/10/2023] [Accepted: 04/20/2024] [Indexed: 05/22/2024] Open
Abstract
BACKGROUND Hantavirus and dengue virus infections lead to diseases causing economic and public health concerns. Acute hantavirus infections can lead to similar clinical haemorrhagic signs as other endemic diseases including dengue and leptospirosis. METHODS Using a retrospective case analysis of pregnant dengue and hantavirus disease patients with clinical reports and compatible clinical laboratory information during pregnancy, we report the first evidence of dengue and hantavirus infections and a case of dual dengue and hantavirus infection among pregnant women in the Caribbean. Laboratory testing by enzyme-linked immunosorbent assay (ELISA) and non-structural protein 1 (NS1) for DENV and for hantavirus infection pseudotype focus reduction neutralisation tests (pFRNT), ELISA and immunochromatographic (ICG) strips. RESULTS Four pregnant cases with acute DENV infections were identified; however, only one out of the four cases (25%) had a detailed medical record to permit abstraction of clinical data. Six hantavirus infected pregnant cases were identified with gestation periods ranged from 36 to 39 weeks; none of the reported patients exhibited previous pregnancy complications prior to hospitalisation and infection. Acute liver damage was observed in three of the six cases (AST readings) who were subsequently diagnosed with hepatitis in pregnancy and variable clinical outcomes were observed with term and pre-term deliveries. CONCLUSIONS Whilst hantavirus infection in pregnancy is rare, consideration should be given to differential diagnosis with fever, kidney involvement, liver involvement, haemorrhagic symptoms and thrombocytopenia in endemic areas with clinically similar diseases such as dengue and leptospirosis.HighlightsFirst recorded case of hantavirus and dengue co-infection in a pregnant woman.First detailed report of clinical hantavirus infection in pregnant women in the Caribbean.First published report of clinical dengue infection in pregnant woman in the Caribbean.Possible complications of pregnancy following hantavirus infection.Pre-term birth and low birth weights.Clinical course of hantavirus infection in a Caribbean population.
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Affiliation(s)
- Kirk Osmond Douglas
- Centre for Biosecurity Studies, University of the West Indies, Cave Hill, St. Michael, Barbados, West Indies
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4
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Chong V, Tan JZL, Arasoo VJT. Dengue in Pregnancy: A Southeast Asian Perspective. Trop Med Infect Dis 2023; 8:86. [PMID: 36828502 PMCID: PMC9964792 DOI: 10.3390/tropicalmed8020086] [Citation(s) in RCA: 2] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/18/2022] [Revised: 01/19/2023] [Accepted: 01/20/2023] [Indexed: 01/31/2023] Open
Abstract
Dengue cases have been rising in recent years. In 2019 alone, over 658,301 of the 5.6 million reported cases originated from Southeast Asia (SEA). Research has also shown detrimental outcomes for pregnant infected women. Despite this, existing literature describing dengue's effects on pregnancy in SEA is insufficient. Through this narrative review, we sought to describe dengue's effects on pregnancy systemically and emphasize the existing gaps in the literature. We extensively searched various journals cited in PubMed and Ovid Medline, national clinical practice guidelines, and governmental reports. Dengue in pregnancy increases the risk of pre-eclampsia, Dengue Hemorrhagic Fever (DHF), fetal distress, preterm delivery, Caesarean delivery, and maternal mortality. Vertical transmission, intrauterine growth restriction, and stillbirth are possible sequelae of dengue in fetuses. We found that trimester-specific physiological impacts of dengue in pregnancy (to both mother and child) and investigations and management methods demanded further research, especially in the SEA region.
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Affiliation(s)
- Vanessa Chong
- Monash School of Medicine, Faculty of Medicine, Nursing & Health Sciences, Monash University Australia, Clayton 3168, Australia
| | - Jennifer Zi Ling Tan
- Monash School of Medicine, Faculty of Medicine, Nursing & Health Sciences, Monash University Australia, Clayton 3168, Australia
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5
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Pham TH, Nguyen PN, Ho QN. Perinatal Transmission of Dengue Infection among Dengue Hemorrhagic Fever Outbreaks in Southern Vietnam: The First Case Managed at Tu Du Hospital and Review of Literature. Am J Trop Med Hyg 2023; 108:155-160. [PMID: 36375466 PMCID: PMC9833081 DOI: 10.4269/ajtmh.22-0572] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/02/2022] [Accepted: 10/02/2022] [Indexed: 11/16/2022] Open
Abstract
Dengue hemorrhagic fever is a high-risk pathology in pregnancy, leading to an increased mortality rate for both the mother and baby. Perinatal transmission of dengue infection may occur during the labor stage of the febrile phase, despite its extreme rarity. In the present case, a young female patient with pregnancy at 39 weeks 3 days of gestational age was hospitalized because of dengue hemorrhagic fever. Upon monitoring, her platelet count gradually decreased to a very low of 13,000 mm3 on the third day of fever. However, her platelet count increased soon afterwards. On the eighth day of admission, she was delivered by emergency cesarean section due to acute fetal distress. The female neonate was promptly assessed by the pediatric team upon cesarean surgery. The neonate was diagnosed with vertical transmission of dengue infection based on positive dengue virus nonstructural protein 1 antigen, and low platelet count was found on the first day postpartum. When there is a high suspicion of perinatal transmission, closely monitoring the newborn helps to avoid the adverse outcomes and mortality for the infant. Herein, we thoroughly report an unusual case of maternal-fetal transmission of dengue during pregnancy at our maternity hospital.
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Affiliation(s)
- Thanh Hai Pham
- Tu Du Clinical Research Unit (TD-CRU), Tu Du Hospital, Ho Chi Minh City, Vietnam
| | - Phuc Nhon Nguyen
- Tu Du Clinical Research Unit (TD-CRU), Tu Du Hospital, Ho Chi Minh City, Vietnam
- Department of High-Risk Pregnancy, Tu Du Hospital, Ho Chi Minh City, Vietnam
| | - Quang Nhat Ho
- Department of Postoperative Care, Tu Du Hospital, Ho Chi Minh City, Vietnam
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6
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Yadav B, Gupta N, Gadepalli R, Nag VL. Neonatal dengue: an under-diagnosed entity. BMJ Case Rep 2021; 14:e241727. [PMID: 34400420 PMCID: PMC8370508 DOI: 10.1136/bcr-2021-241727] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 06/10/2021] [Indexed: 11/04/2022] Open
Abstract
Neonatal dengue is an under-diagnosed disease likely due to low index of suspicion along with its resemblance to sepsis. We hereby report two cases of neonatal dengue, highlighting the need of high degree of suspicion in infants born to febrile mothers even with maternal serology being negative. Moreover, severity of neonatal illness positively correlates with the maternal disease.
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Affiliation(s)
- Bharti Yadav
- Department of Neonatology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
| | - Neeraj Gupta
- Department of Neonatology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
| | - Ravisekhar Gadepalli
- Department of Microbiology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
| | - Vijaya Lakshmi Nag
- Department of Microbiology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
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7
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Nkenfou CN, Fainguem N, Dongmo-Nguefack F, Yatchou LG, Kameni JJK, Elong EL, Samie A, Estrin W, Koki PN, Ndjolo A. Enhanced passive surveillance dengue infection among febrile children: Prevalence, co-infections and associated factors in Cameroon. PLoS Negl Trop Dis 2021; 15:e0009316. [PMID: 33861747 PMCID: PMC8051767 DOI: 10.1371/journal.pntd.0009316] [Citation(s) in RCA: 18] [Impact Index Per Article: 4.5] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/03/2020] [Accepted: 03/16/2021] [Indexed: 11/18/2022] Open
Abstract
Dengue virus (DENV) causes a spectrum of diseases ranging from asymptomatic, mild febrile to a life-threatening illness: dengue hemorrhagic fever. The main clinical symptom of dengue is fever, similar to that of malaria. The prevalence of dengue virus infection, alone or in association with other endemic infectious diseases in children in Cameroon is unknown. The aim of this study was to determine the prevalence of dengue, malaria and HIV in children presenting with fever and associated risk factors. Dengue overall prevalence was 20.2%, Malaria cases were 52.7% and HIV cases represented 12.6%. The prevalence of dengue-HIV co-infection was 6.0% and that of Malaria-dengue co-infection was 19.5%. Triple infection prevalence was 4.3%. Dengue virus infection is present in children and HIV-Dengue or Dengue- Malaria co-infections are common. Dengue peak prevalence was between August and October. Sex and age were not associated with dengue and dengue co-infections. However, malaria as well as HIV were significantly associated with dengue (P = 0.001 and 0.028 respectively). The diagnosis of dengue and Malaria should be carried out routinely for better management of fever. Fever is a symptom common to several infectious diseases such as malaria, yellow fever, dengue fever and typhoid which are all present in Cameroon. In most cases, fever in Cameroon is assumed to be due to malaria and treated as such. This study present the prevalence of dengue fever among febrile children. Dengue fever as well as malaria is common among Cameroonian children. Since Cameroon is endemic for malaria, fever may indicate either malaria or dengue. Clinicians should be aware of the presence of dengue in Cameroon. Knowing the risk factors, parents are encouraged to use the bed net to protect their children and clean stagnant water from their environment. Children could be co-infected by dengue, malaria as well as HIV. Management of patients with dengue fever and HIV infection should be studied, especially in infants where both viral diseases are more severe. Close monitoring may prevent complications among HIV-infected individuals who contract dengue fever.
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Affiliation(s)
- Celine Nguefeu Nkenfou
- “Chantal Biya” International Reference Centre for Research on HIV and AIDS Prevention and Management (CIRCB), Yaoundé, Cameroon
- University of Yaoundé I, Higher Teachers’ Training College, Department of Biology, Yaoundé, Cameroon
- * E-mail:
| | - Nadine Fainguem
- “Chantal Biya” International Reference Centre for Research on HIV and AIDS Prevention and Management (CIRCB), Yaoundé, Cameroon
| | - Félicitée Dongmo-Nguefack
- Mother and Child Centre of the Chantal Biya Foundation, Pediatric Service, Yaoundé, Cameroon
- University of Yaoundé I, Faculty of Medicine and Biomedical Sciences, Yaoundé, Cameroon
| | - Laeticia Grace Yatchou
- “Chantal Biya” International Reference Centre for Research on HIV and AIDS Prevention and Management (CIRCB), Yaoundé, Cameroon
| | - Joel Josephine Kadji Kameni
- “Chantal Biya” International Reference Centre for Research on HIV and AIDS Prevention and Management (CIRCB), Yaoundé, Cameroon
| | - Elise Lobe Elong
- “Chantal Biya” International Reference Centre for Research on HIV and AIDS Prevention and Management (CIRCB), Yaoundé, Cameroon
| | - Amidou Samie
- Department of Microbiology, University of Venda, Venda, South Africa
| | - William Estrin
- California Pacific Medical Center, San Francisco, CA, United States of America
| | - Paul Ndombo Koki
- Mother and Child Centre of the Chantal Biya Foundation, Pediatric Service, Yaoundé, Cameroon
- University of Yaoundé I, Faculty of Medicine and Biomedical Sciences, Yaoundé, Cameroon
| | - Alexis Ndjolo
- “Chantal Biya” International Reference Centre for Research on HIV and AIDS Prevention and Management (CIRCB), Yaoundé, Cameroon
- University of Yaoundé I, Faculty of Medicine and Biomedical Sciences, Yaoundé, Cameroon
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8
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Clinical features and outcomes of neonatal dengue at the Children's Hospital 1, Ho Chi Minh, Vietnam. J Clin Virol 2021; 138:104758. [PMID: 33862538 DOI: 10.1016/j.jcv.2021.104758] [Citation(s) in RCA: 4] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/29/2020] [Revised: 02/05/2021] [Accepted: 02/07/2021] [Indexed: 11/22/2022]
Abstract
Objectives Neonatal dengue has been reported in the literature with contradictory findings of clinical characteristics and diagnosis; thereby, misdiagnosis of neonatal dengue has been frequently reported. We aim to delve into the epidemiology, clinical features, and outcomes of neonatal dengue, thus avoid misdiagnosis and obtain early intervention. Study design A retrospective study was conducted at Children's Hospital 1, Ho Chi Minh, Vietnam with laboratory-confirmed dengue in neonates by positive viral antigen nonstructural protein one rapid test (NS1) and positive IgM antibody for dengue by MAC-ELISA. Results We have included 32 neonates in this study with 25% cases were misdiagnosed with neonatal sepsis, and 12.5% cases were misdiagnosed with neonatal immune thrombocytopenia at the beginning. The median time between the first day of the mother's onset of fever and childbirth was -1 days (IQR: -2, 2). The patient's clinical manifestation included: petechiae 87.5% (28/32), pharyngeal mucosal hemorrhage 6.3% (2/32), and hepatomegaly occurred 75% (24/32). In the febrile phase (day of illness 1-3), the mean white blood cell (WBC) counts were 7800 ± 800/mm3 and platelets were 97,111 ± 37,826/mm3. In the critical phase (day of illness 4-6), the mean WBC counts were 13,400 ± 2800/mm3, and platelets were 30,100 ± 5749/mm3. All mothers (100%) had laboratory-confirmed dengue by NS1 positive in the perinatal period. Conclusions The findings emphasize that early diagnosis of neonatal dengue should be based on a history of maternal illness, NS1 rapid test, and clinical presentation such as petechiae, hepatomegaly, and low platelet counts in the febrile phase.
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9
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Haryanto S, Yohan B, Santoso MS, Hayati RF, Denis D, Udjung GIVW, Kendarsari RI, Trimarsanto H, Sasmono RT. Clinical features and virological confirmation of perinatal dengue infection in Jambi, Indonesia: A case report. Int J Infect Dis 2019; 86:197-200. [PMID: 31357059 DOI: 10.1016/j.ijid.2019.07.019] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/15/2019] [Revised: 07/18/2019] [Accepted: 07/22/2019] [Indexed: 11/17/2022] Open
Abstract
The hyper-endemicity of dengue in Indonesia poses a significant threat of dengue virus (DENV) vertical transmission during pregnancy. A 29-year-old female at 38 weeks of pregnancy presented to hospital with acute fever and later confirmed with DENV infection. Due to signs of fetal distress, the neonate was delivered by emergency caesarean section. The mother developed a dengue critical phase post-caesarean with excessive bleeding and required blood transfusion. During the 6th day of life, the neonate was diagnosed and later confirmed with dengue. Next-generation sequencing of DENV RNA isolated directly from sera of both mother and neonate revealed identical DENV-2 whole-genome sequences. Plaque reduction neutralization test (PRNT) detected anti-dengue antibodies in both mother and neonate. Altogether, our data confirmed the occurrence of vertical transmission. Dengue vertical transmission during pregnancy may lead to severe manifestation, hence early diagnosis, close monitoring, and prompt intervention are critical.
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Affiliation(s)
| | - Benediktus Yohan
- Eijkman Institute for Molecular Biology, Ministry of Research, Technology, and Higher Education of the Republic of Indonesia, Jakarta, Indonesia
| | - Marsha Sinditia Santoso
- Eijkman Institute for Molecular Biology, Ministry of Research, Technology, and Higher Education of the Republic of Indonesia, Jakarta, Indonesia
| | - Rahma F Hayati
- Eijkman Institute for Molecular Biology, Ministry of Research, Technology, and Higher Education of the Republic of Indonesia, Jakarta, Indonesia
| | - Dionisius Denis
- Eijkman Institute for Molecular Biology, Ministry of Research, Technology, and Higher Education of the Republic of Indonesia, Jakarta, Indonesia
| | | | - R Indah Kendarsari
- Eijkman Institute for Molecular Biology, Ministry of Research, Technology, and Higher Education of the Republic of Indonesia, Jakarta, Indonesia
| | - Hidayat Trimarsanto
- Eijkman Institute for Molecular Biology, Ministry of Research, Technology, and Higher Education of the Republic of Indonesia, Jakarta, Indonesia
| | - R Tedjo Sasmono
- Eijkman Institute for Molecular Biology, Ministry of Research, Technology, and Higher Education of the Republic of Indonesia, Jakarta, Indonesia.
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10
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Almeida Bentes A, Kroon EG, Romanelli RMDC. Neurological manifestations of pediatric arboviral infections in the Americas. J Clin Virol 2019; 116:49-57. [DOI: 10.1016/j.jcv.2019.04.006] [Citation(s) in RCA: 9] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/08/2019] [Revised: 04/21/2019] [Accepted: 04/23/2019] [Indexed: 01/17/2023]
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11
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Hsu AY, Ho TC, Lai ML, Tan SS, Chen TY, Lee M, Chien YW, Chen YP, Perng GC. Identification and characterization of permissive cells to dengue virus infection in human hematopoietic stem and progenitor cells. Transfusion 2019; 59:2938-2951. [PMID: 31251408 DOI: 10.1111/trf.15416] [Citation(s) in RCA: 7] [Impact Index Per Article: 1.2] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/06/2019] [Revised: 05/16/2019] [Accepted: 05/17/2019] [Indexed: 01/26/2023]
Abstract
BACKGROUND Dengue virus (DENV) is a significant threat to public health in tropical and subtropical regions, where the frequency of human migration is increasing. Transmission of DENV from donors to recipients after hematopoietic stem cell transplantation has been steadily described. However, the underlying mechanisms remain unclear. STUDY DESIGN AND METHODS Freshly isolated bone marrow (BM) was subjected to DENV infection, followed by multicolor fluorescence-activated cell sorting (FACS) analysis. Virus in supernatants was collected and analyzed by plaque assay. RESULTS DENV-1 to DENV-4 could effectively infect freshly obtained BM and produced infectious virus. DENV infection did not change the quantitative population of hematopoietic stem and progenitor cells (HSPCs), megakaryocytic progenitor cells (MkPs) and megakaryocytes. Additionally, DENV antigen, nonstructural protein 1, was enriched in HSPCs and MkPs of DENV infected marrow cells. CD34+, CD133+, or CD61+ cells sorted out from BM were not only the major contributing targets facilitating the DENV infection directly but also facilitated the spread of DENV into other cells when cocultured. CONCLUSION Results suggest that DENV can efficiently infect HSPCs, which might jeopardize the recipients if DENV-infected cells were subsequently used. We therefore raise the need for DENV screening for both the donors and recipients of hematopoietic stem cell transplantation, especially for donors exposed to endemic areas, to mitigate DENV infection in immunocompromised recipients.
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Affiliation(s)
- Alan Y Hsu
- Department of Microbiology and Immunology, National Cheng Kung University, Tainan, Taiwan.,Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.,Department of Biological Sciences, Purdue University, West Lafayette, Indiana
| | - Tzu-Chuan Ho
- Department of Microbiology and Immunology, National Cheng Kung University, Tainan, Taiwan.,Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan
| | - Mei-Ling Lai
- Department of Microbiology and Immunology, National Cheng Kung University, Tainan, Taiwan
| | - Sia Seng Tan
- Department of Microbiology and Immunology, National Cheng Kung University, Tainan, Taiwan
| | - Tsai-Yun Chen
- Division of Hematology and Oncology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
| | - Meed Lee
- Department of Microbiology and Immunology, National Cheng Kung University, Tainan, Taiwan
| | - Yu-Wen Chien
- Departement of Public Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan
| | - Ya-Ping Chen
- Division of Hematology and Oncology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
| | - Guey Chuen Perng
- Department of Microbiology and Immunology, National Cheng Kung University, Tainan, Taiwan.,Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan
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12
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Goldenberg RL, McClure EM. Dengue and stillbirth. THE LANCET. INFECTIOUS DISEASES 2018; 17:886-888. [PMID: 28845788 DOI: 10.1016/s1473-3099(17)30455-3] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Track Full Text] [Subscribe] [Scholar Register] [Received: 06/30/2017] [Accepted: 07/07/2017] [Indexed: 11/28/2022]
Affiliation(s)
- Robert L Goldenberg
- Department of Obstetrics and Gynecology, Columbia University, New York, NY 10032, USA.
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13
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Souza AI, Ferreira ALCG, Arraes MA, Moura BM, Braga MC. Dengue as a cause of fever during pregnancy: a report of two cases. Rev Soc Bras Med Trop 2017; 49:380-2. [PMID: 27384840 DOI: 10.1590/0037-8682-0306-2015] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/09/2015] [Accepted: 01/06/2016] [Indexed: 11/22/2022] Open
Abstract
Dengue infection has not been routinely investigated among pregnant women and parturients with acute febrile syndrome in endemic settings. Here, we report two cases of dengue fever detected at the time of delivery in parturients enrolled in a cohort prospective study conducted in a hospital in Recife, Brazil. The parturients reported fever onset within seven days prior to delivery, and dengue infection was confirmed upon detection of viral ribonucleic acid (RNA) by using the reverse transcriptase-polymerase chain reaction. Dengue infection should be considered as a diagnostic possibility in cases of fever during pregnancy and labor, especially in endemic areas.
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Affiliation(s)
- Ariani Impieri Souza
- Programa de Pós-Graduação Stricto Sensu em Saúde Materno Infantil, Instituto de Medicina Integral Professor Fernando Figueira, Recife, Pernambuco, Brasil.,Curso de Medicina, Faculdade Pernambucana de Saúde, Recife, Pernambuco, Brasil
| | - Ana Laura Carneiro Gomes Ferreira
- Programa de Pós-Graduação Stricto Sensu em Saúde Materno Infantil, Instituto de Medicina Integral Professor Fernando Figueira, Recife, Pernambuco, Brasil
| | | | - Bruno Marcelo Moura
- Curso de Medicina, Faculdade Pernambucana de Saúde, Recife, Pernambuco, Brasil
| | - Maria Cynthia Braga
- Programa de Pós-Graduação Stricto Sensu em Saúde Materno Infantil, Instituto de Medicina Integral Professor Fernando Figueira, Recife, Pernambuco, Brasil.,Departamento de Parasitologia, Centro de Pesquisas Aggeu Magalhães, Fundação Oswaldo Cruz, Recife, Pernambuco, Brasil
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14
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Jain J, Dubey SK, Shrinet J, Sunil S. Dengue Chikungunya co-infection: A live-in relationship?? Biochem Biophys Res Commun 2017; 492:608-616. [PMID: 28189673 DOI: 10.1016/j.bbrc.2017.02.008] [Citation(s) in RCA: 14] [Impact Index Per Article: 1.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/02/2016] [Revised: 01/18/2017] [Accepted: 02/03/2017] [Indexed: 11/24/2022]
Abstract
Dengue and Chikungunya are viral infections that are a major public health hazard in recent times. Both these infections are caused by RNA viruses termed arboviruses owing to their requirement of an arthropod vector to get transmitted to vertebrate hosts. Apart from sharing a common vector, namely Aedes mosquitoes, these infections are also characterized by overlapping clinical presentations and are known to exist as co-infection. The present review traces the history and evolution of co-infection across the globe and provides specific compilation of the scenario in India. Furthermore, clinical manifestations during co-infection are discussed. Lastly, up-to-date information with respect to vector behaviour during co-infection both under laboratory conditions and in natural Aedes populations is reviewed.
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Affiliation(s)
- Jaspreet Jain
- Vector Borne Disease Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi, 110067, India
| | - Sunil Kumar Dubey
- Vector Borne Disease Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi, 110067, India
| | - Jatin Shrinet
- Vector Borne Disease Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi, 110067, India
| | - Sujatha Sunil
- Vector Borne Disease Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi, 110067, India.
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15
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Chen LH, Wilson ME. Update on non-vector transmission of dengue: relevant studies with Zika and other flaviviruses. Trop Dis Travel Med Vaccines 2016; 2:15. [PMID: 28883959 PMCID: PMC5530933 DOI: 10.1186/s40794-016-0032-y] [Citation(s) in RCA: 27] [Impact Index Per Article: 3.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/13/2016] [Accepted: 08/13/2016] [Indexed: 12/31/2022] Open
Abstract
Human dengue virus infection without mosquito vector has been reported to occur as a result of mucocutaneous transmission, needlestick in patient care and laboratory accident, blood transfusion, bone marrow transplant, organ transplant, intrapartum and perinatal transmission, and breastfeeding. The emergence of Zika virus, another mosquito-borne flavivirus, has illustrated additional potential routes of non-vector transmission in humans. A recent study in another flavivirus, Japanese encephalitis virus, in pigs has also demonstrated non-vector transmission. We highlight some reports on dengue virus that have documented non-vector transmission and that are relevant to the transmission of Zika virus and other flaviviruses.
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Affiliation(s)
- Lin H. Chen
- Travel Medicine Center, Mount Auburn Hospital, Cambridge, MA USA
- Faculty of Medicine, Harvard Medical School, Boston, MA USA
- Division of Infectious Diseases, Mount Auburn Hospital, 330 Mount Auburn Street, Cambridge, MA 02138 USA
| | - Mary Elizabeth Wilson
- Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA USA
- Department of Epidemiology and Biostatistics at University of California San Francisco, San Francisco, CA USA
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Taylor A, Foo SS, Bruzzone R, Dinh LV, King NJC, Mahalingam S. Fc receptors in antibody-dependent enhancement of viral infections. Immunol Rev 2016; 268:340-64. [PMID: 26497532 PMCID: PMC7165974 DOI: 10.1111/imr.12367] [Citation(s) in RCA: 181] [Impact Index Per Article: 20.1] [Reference Citation Analysis] [Abstract] [Key Words] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/17/2022]
Abstract
Sensitization of the humoral immune response to invading viruses and production of antiviral antibodies forms part of the host antiviral repertoire. Paradoxically, for a number of viral pathogens, under certain conditions, antibodies provide an attractive means of enhanced virus entry and replication in a number of cell types. Known as antibody‐dependent enhancement (ADE) of infection, the phenomenon occurs when virus‐antibody immunocomplexes interact with cells bearing complement or Fc receptors, promoting internalization of the virus and increasing infection. Frequently associated with exacerbation of viral disease, ADE of infection presents a major obstacle to the prevention of viral disease by vaccination and is thought to be partly responsible for the adverse effects of novel antiviral therapeutics such as intravenous immunoglobulins. There is a growing body of work examining the intracellular signaling pathways and epitopes responsible for mediating ADE, with a view to aiding rational design of antiviral strategies. With in vitro studies also confirming ADE as a feature of infection for a growing number of viruses, challenges remain in understanding the multilayered molecular mechanisms of ADE and its effect on viral pathogenesis.
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Affiliation(s)
- Adam Taylor
- Emerging Viruses and Inflammation Research Group, Institute for Glycomics, Griffith University, Gold Coast, Qld, Australia
| | - Suan-Sin Foo
- Emerging Viruses and Inflammation Research Group, Institute for Glycomics, Griffith University, Gold Coast, Qld, Australia
| | - Roberto Bruzzone
- HKU-Pasteur Research Pole, School of Public Health, The University of Hong Kong, Hong Kong SAR, Hong Kong.,Department of Cell Biology and Infection, Institut Pasteur, Paris, France
| | - Luan Vu Dinh
- Discipline of Pathology, Bosch Institute, School of Medical Sciences, Sydney Medical School, Charles Perkins Centre, University of Sydney, Sydney, NSW, Australia
| | - Nicholas J C King
- Discipline of Pathology, Bosch Institute, School of Medical Sciences, Sydney Medical School, Charles Perkins Centre, University of Sydney, Sydney, NSW, Australia
| | - Suresh Mahalingam
- Emerging Viruses and Inflammation Research Group, Institute for Glycomics, Griffith University, Gold Coast, Qld, Australia
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