1400W reduces ischemia reperfusion injury in an ex-vivo porcine model of the donation after circulatory death kidney donor

Table 1 Acid base balance, levels of pH, bicarbonate and potassium pre and 3 h after reperfusion

	Control		1400W
	Pre	3 h	Pre	3 h
pH	7.43 ± 0.03	7.30 ± 0.08	7.47 ± 0.04	7.24 ± 0.04
Bicarbonate (mmol/L)	21.2 ± 1.4	17.3 ± 3.0	23.4 ± 1.6	17.6 ± 2.1
Potassium (mmol/L)	5.5 ± 0.3a	10.7 ± 1.3	5.9 ± 0.2	11.9 ± 0.3

^aP < 0.05 between groups. Mann Whitney U-test.

Table 2 Histology score

	Control		1400W
	Pre	Post	Pre	Post
Tubular dilatation	0.91 ± 0.68	1.60 ± 0.60a	2.03 ± 0.80b	1.63 ± 0.81
Tubular debris	1.44 ± 0.50	1.14 ± 0.73	1.47 ± 0.50	2.07 ± 0.74ab
Vacuolation	0.52 ± 0.76	1.09 ± 1.091	0.50 ± 0.60	1.00 ± 0.91a
Interstitial oedema	1.33 ± 0.48b	1.29 ± 0.52	0.93 ± 0.70	1.47 ± 0.82a

Pre and post reperfusion biopsies in the control and 1400W groups. Biopsies were scored over 5 fields assessing tubular dilatation, tubular debris, vacuolation and interstitial oedema.

^aP≤ 0.05 between time points,

^bP≤ 0.05 between groups. Mann Whitney U-test.