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World J Transplant. Dec 24, 2014; 4(4): 294-298
Published online Dec 24, 2014. doi: 10.5500/wjt.v4.i4.294
Role of liver transplantation in the management of hepatoblastoma in the pediatric population
Saira Khaderi, Jacfranz Guiteau, Ronald T Cotton, Christine O’Mahony, Abbas Rana, John A Goss, Division of Abdominal Transplantation, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, United States
Author contributions: Khaderi S and Guiteau J wrote the manuscript; Cotton RT and Rana A performed the statistical analysis and assisting in writing the manuscript; O’Mahony C and Goss JA provided expertise regarding pediatric transplantation and assisted in writing the manuscript.
Correspondence to: Saira Khaderi, MD, MPH, Assistant Professor of Surgery, Division of Abdominal Transplantation, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, 6620 Main Street, Suite 1425, Houston, TX 77030, United States. khaderi@bcm.edu
Telephone: +1-832-3551400 Fax: +1-713-6102479
Received: August 12, 2014
Revised: October 21, 2014
Accepted: October 28, 2014
Published online: December 24, 2014
Processing time: 139 Days and 8 Hours

Abstract

Hepatoblastoma (HB) is the most common primary liver tumor in children and accounts for two-thirds of all malignant liver neoplasms in the pediatric population. For patients with advanced HB (unresectable or unresponsive to chemotherapy), combined treatment with chemotherapy and liver transplantation is an excellent option. The etiology of HB is mostly obscure because of its extreme rarity although some inherited syndromes and very low birth weight have been associated with it. The prognosis for children with HB has significantly improved in the past three decades thanks to advancements in chemotherapy, surgical resection and postoperative care. In 2002 a surgical staging system called pretreatment extent of disease (PRETEXT) was designed to allow a universal, multidisciplinary approach to patients with HB. Between one-third to two-thirds of patients initially present with unresectable tumors or distant metastases, but up to 85% of these tumors become operable after neoadjuvant chemotherapy. Patients with PRETEXT categories 1, 2, and some 3 are referred for neoadjuvant chemotherapy followed by surgical resection with the goal of complete tumor removal. Classic treatments regimens include a combination of cisplatin, fluorouracil, and vincristine or cisplatin and doxorubicin. Liver transplantation is the only treatment option for unresectable HB. In 2010 the pediatric end-stage liver disease, a pediatric-specific scoring system that determines a patient’s ranking on the liver transplant list, began to award additional “exception” points for patients with HB. We analyzed the Standard Transplant Analysis and Research dataset to assess the impact of changes in exception point criteria for HB on outcomes after liver transplantation at Texas Children’s Hospital in Houston, Texas. We found that patients who were listed for transplantation with current HB exception criteria experienced a shorter waitlist time but survival was similar between the two eras.

Key Words: Liver transplant; Hepatoblastoma; Pediatric; Chemotherapy; Cancer

Core tip: Hepatoblastoma (HB) is the most common primary liver tumor in children. Between one-third to two-thirds of patients present with unresectable tumors or distant metastases, but up to 85% of these tumors become operable after neoadjuvant chemotherapy. Liver transplantation is the only treatment option for unresectable HB. In 2010 the pediatric end-stage liver disease scoring system began to award additional “exception” points for patients with HB. We analyzed the Standard Transplant Analysis and Research dataset and found that patients who were listed for transplantation with current HB exception criteria experienced a shorter waitlist time but survival was similar between the two eras.



INTRODUCTION

Hepatoblastoma (HB) is the most common primary liver tumor in children and accounts for two-thirds of all malignant liver neoplasms in the pediatric population[1]. Standard treatment of HB includes neoadjuvant chemotherapy and surgical resection followed by adjuvant chemotherapy. For patients with advanced HB (unresectable or unresponsive to chemotherapy), combined treatment with chemotherapy and liver transplantation is an excellent option[2]. This article briefly reviews the epidemiology and treatment of HB in the pediatric population with an emphasis on the role of orthotopic liver transplantation (OLT).

EPIDEMIOLOGY

The etiology of HB is mostly obscure because of its extreme rarity. The rate of HB in the United States Surveillance, Epidemiology, and End Results (SEER) from 2002-2008 was 10.5 cases per million in children less than one year of age and 5.2 cases per million in children 1 through 4 years of age[3]. It is assumed the tumor originates in utero for two reasons. Histologically HB cells resemble embryonal liver cells and the incidence is highest at birth suggesting the process is initiated during gestation[4].

Some inherited syndromes have been associated with HB. Incidence of HB among children with Familial Adenomatous Polyposis was found to be 847 times the incidence in the SEER population[5]. Those with the Beckwith-Wiedemann overgrowth syndrome had an incidence 2280 times that of the United States population of the same age[6]. Although these inherited conditions raise the risk of HB, they account for only a few cases overall.

Very low birth weight (< 1500 g) increases the risk of HB in children 20-fold and moderate low birth weight (1500-2500 g) doubles the risk[7]. The association of low birth weight and HB has two explanations. HB may be initiated or promoted by iatrogenic hazards in the neonatal intensive care units[8] in combination with decreased antioxidant defense mechanisms of pre-term infants[9]. Alternatively, HB and very low birth weight may share a common mechanism and the increase in survival of these patients has made the association more apparent.

TREATMENT

The prognosis for children with HB has significantly improved in the past three decades thanks to advancements in chemotherapy, surgical resection and postoperative care[10]. Prior to the discovery of effective chemotherapy, cure was limited to completely resectable tumors and overall survival was dismal[10].

Early experiences with successful cure were sporadic at best and were limited to lesions that could be completely resected. In 2002 a staging system called the PRETreatment EXTent of disease (PRETEXT) was designed to allow a universal, multidisciplinary approach to patients with HB (Figure 1). The main aim of PRETEXT grouping was to identify patients in whom complete tumor resection was possible with a partial hepatectomy. Physicians placed patients in one of four PRETEXT categories based on the extent of their tumor on imaging. The liver is divided into four sectors in the PRETEXT system - anterior and posterior on the right and a medial and lateral sector on the left. Four groups were identified based on tumor extension: PRETEXT I, tumor only in one sector; PRETEXT II, tumor involves two sectors; PRETEXT III, tumor involves three sectors or two non-adjoining sectors; and PRETEXT 4, tumor involves all four sectors[11]. These categories are further characterized by describing extrahepatic spread: V for involvement of the hepatic veins and/or inferior vena cava, P for involvement of the portal vein, E for extrahepatic tumor extension, and M for distant metastases[11].

Figure 1
Figure 1 Pretreatment (pretreatment extent of disease) grouping system. Printed with permission from Baylor College of Medicine.

Between one-third to two-thirds of patients initially present with unresectable tumors or distant metastases, but up to 85% of these tumors become operable after neoadjuvant chemotherapy[12]. Preoperative chemotherapy has many advantages. It is responsible for making tumors smaller and more demarcated from the surrounding liver. Most surgeons agree that operating on tumors that shrink with chemotherapy is easier because the tumor is more defined and less prone to bleeding. It also exposes metastases (both visible and micrometastases) to chemotherapy earlier. In one trial, up to 52% of patients with initial lung metastases achieved complete remission with chemotherapy alone[13]. Classic treatment regimens include a combination of cisplatin, fluorouracil, and vincristine or cisplatin and doxorubicin. Although an effective agent, patients treated with doxorubicin can have a higher incidence of treatment complications and toxic death-especially from heart failure[14]. More recent studies have shown the effectiveness of single-agent cisplatin treatment in both standard and high-risk patients with HB[15,16] decreasing the likelihood of chemotherapy-induced toxicity.

Patients with PRETEXT categories 1, 2, and some 3 are referred for neoadjuvant chemotherapy followed by surgical resection with the goal of complete tumor removal. Current chemotherapy at our institution consists of cisplatin, 5-fluorouracil, and vincristine or vincristine and doxorubicin. Patients will undergo four rounds of chemotherapy prior to resection and two rounds after resection. Disease-free survival following partial liver resection under these circumstances has been reported to be greater than 70%[2]. It has been argued that tumors with favorable prognostic factors, such as pure fetal histology and low mitotic rate, may not require toxic chemotherapy and should be treated with surgical resection only[17]. However, the treatment regimen at our institution closely follows the precedent set forth in European studies which emphasize the use of neoadjuvant chemotherapy in all HB patients because of the high frequency of HB chemosensitivity[11,18].

Liver transplant

Liver transplantation is the only treatment option for unresectable HB. Transplant should be considered in the following cases: multifocal disease (PRETEXT IV), PRETEXT III with the tumor in close proximity to major vessels, and tumor extension into major vessels. Patients that fall into these categories at our institution are listed for OLT immediately after the diagnosis of HB is confirmed and undergo chemotherapy while they await transplantation. Overall patient survival at 6 years has been reported to be over 80% making OLT the preferred treatment modality in this group[19]. Patients with intrahepatic recurrence or residual tumor after resection are rarely candidates for transplant because of poor outcomes[19].

There are few contraindications to OLT for unresectable HB. Patients with persistent pulmonary metastases despite neoadjuvant therapy and those with viable extrahepatic tumor not amenable to resection are not candidates for OLT. Patients that present with lung metastases are candidates for OLT if their lung metastases resolve with chemotherapy or with resection. Those with extrahepatic disease that remains viable after full chemotherapy and not amenable to surgical resection represent the only absolute contraindication to OLT in patients with HB[19].

Organ allocation rules for children with HB have changed over the past decade. The pediatric end-stage liver disease (PELD) is a pediatric-specific scoring system that was adopted in 2002 to help determine a patient’s ranking on the liver transplant list. The effect of the system has been to decrease the rate of death and removal from the transplant list and increase the percentage of children who receive a deceased donor organ. The score is based on total bilirubin, coagulopathy, serum albumin, age < 1 year and growth failure, but additional “exception” points may be awarded for risk factors not represented by the PELD equation. For example, patients with unresectable HB are listed with a PELD score of 30 for 30 d and are increased to status 1B if they have not been transplanted.

We analyzed the Standard Transplant Analysis and Research dataset to assess the impact of changes in exception point criteria for HB on outcomes after liver transplantation at Texas Children’s Hospital in Houston, Texas. Patients who underwent orthotopic liver transplant in our center from 1987-2014 with recipient diagnosis of either HB, cirrhosis post-resection of HB, or for whom a MELD exception was granted for non-metastatic HB were selected for analysis. Patients were grouped based on date of initial listing for transplantation. The 1987-2009 era preceded the current policy for HB exception while the 2010-2014 era followed its implementation. Differences in age at listing, recipient gender, waitlist time, and post-transplant patient survival between the two groups were calculated. To examine the difference between the number of patients listed in each era, a one-sample binomial test was used. Independent samples Mann-Whitney U testing was performed to compute differences in means between the two groups, while Pearson’s Chi-Squared was employed for differences in frequencies. Actuarial survival was assessed via the Kaplan-Meier Method. All statistical computations were performed with SPSS version 22 (IBM Armonk, New York).

Descriptive statistics for patients transplanted in each era are displayed in Table 1. A statistically similar number of patients were transplanted in each group (7 vs 14, P = 0.189). Similarly, there was no significant difference in gender, age at listing, and age at transplantation between the two eras. Patients listed for transplantation with the current HB exception criteria experienced a shorter waitlist time (45.5 d vs 25.4 d, P = 0.025).

Table 1 Pediatric patients transplanted for hepatoblastoma at our center before (Era 1) and after (Era 2) implementation of pediatric end-stage liver disease exception points for hepatoblastoma.
Era 1 (1987-2009)Era 2 (2010-2014)Significance (P-value)
Total patients listed for transplantation7140.189
Gender0.557
Male57.10%35.70%
Female42.90%64.30%
Age at listing (yr)5.420.094
Age at transplant (yr)5.62.10.110
Waitlist time (d)45.625.40.025

Figure 2 demonstrates patient survival in our center before and after implementation of the revised HB exception policy. From 1987-2009, 30-d, one-year, and five-year survival following liver transplant in our center was 98.6%, 87.0%, and 77.4%, respectively. In comparison, 30-d, one-year survival following transplantation from 2010-2014 was 97.1% and 90.5%. Statistically, patient survival is similar between the two eras (P = 0.7).

Figure 2
Figure 2 Patient survival by Era of transplantation.
CONCLUSION

In conclusion, standard treatment with neoadjuvant chemotherapy, surgical resection followed by adjuvant chemotherapy is a good option for most pediatric and adolescent patients with HB. For those with tumors that are unresectable or unresponsive to chemotherapy, combined treatment with chemotherapy and liver transplantation is an excellent option. PELD exception points for HB have decreased the wait time for most patients listed for transplant but it is too soon to determine if this translates into increased survival for the group.

ACKNOWLEDGMENTS

We would like to thank Scott Holmes, board certified medical illustrator with Baylor College of Medicine, for his help with the illustration.

Footnotes

P- Reviewer: Hori T, Qin JM S- Editor: Ji FF L- Editor: A E- Editor: Lu YJ

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