Comparison of Clavien–Dindo classification and comprehensive complication index in patients undergoing simultaneous pancreas-kidney transplantation

Table 1 Demographics and baseline characteristics of all patients undergoing simultaneous pancreas-kidney transplantation, n (%)

Characteristic	Whole cohort (n = 128)	No complication (n = 59)	At least one complication (n = 69)	P value
Age (years), mean ± SD	40.9 ± 7.4	39.8 ± 7.5	41.9 ± 7.3	0.120
Male	84 (65.6)	35 (59.3)	49 (71.1)	0.165
Female	44 (34.4)	24 (40.7)	20 (29.0)	-
BMI, kg/m2, mean ± SD	25.4 ± 3.9	24.8 ± 4.0	25.8 ± 3.9	0.244
Indication for transplant type 1 DM	128 (100)	59 (100)	69 (100)	-
Age (years) at diagnosis of type 1 DM, mean ± SD	12.9 ± 7.5	12.7 ± 7.6	13.2 ± 7.5	0.677
Duration (years) of diabetes, mean ± SD	36.3 ± 9.6	35.4 ± 9.2	37.1 ± 9.9	0.329
Vascular pretx
Macro1	45 (35.1)	19 (32.2)	26 (37.7)	0.518
Micro	128 (100)	59 (100)	69 (100)	-
Comorbidities pretx
Hypertension	105 (82)	45 (76.3)	60 (87.0)	0.117
Dyslipidemia	87 (68)	38 (64.4)	49 (71.0)	0.424
CKD	128 (100)	59 (100)	69 (100)	-
Stroke	1 (0.8)	1 (1.7)	0 (0)	0.278
MI	1 (0.8)	1 (1.7)	0 (0)	0.278

¹These include pre-transplant myocardial infarction, cerebrovascular events, peripheral vascular disease.

BMI: Body mass index; DM: Diabetes mellitus; CKD: End-stage chronic kidney disease; MI: Myocardial infarction.

Table 2 Multivariable linear regression of factors associated with length of stay

Factor	Univariable		Multivariable 1		Multivariable 2
	Coefficient	P value	Coefficient	P value	Coefficient	P value
CCI	5.27 (3.86-6.68)	< 0.001	5.96 (4.14-7.77)	< 0.001	-	-
CDC	5.01 (3.41-6.61)	< 0.001	-	-	5.37 (3.36-7.39)	< 0.001
Age	0.08 (-0.34 to 0.50)	0.709	-0.27 (-0.78 to 0.25)	0.309	-0.22 (-0.77 to 0.33)	0.436
BMI	0.06 (-0.91 to 1.03)	0.904	-0.11 (-0.95 to 0.74)	0.802	-0.01 (-0.91 to 8.91)	0.985
Female (compared to male)	4.18 (-2.46 to 10.81)	0.215	8.14 (1.39-14.89)	0.019	7.91 (0.70-15.11)	0.032
Duration of diabetes	0.241 (-0.10 to 0.58)	0.166	0.26 (-0.12 to 0.64)	0.171	0.31 (-0.10 to 0.71)	0.134
Macrovascular1	4.90 (-1.64 to 11.45)	0.141	7.82 (1.25-14.38)	0.020	8.19 (1.20-15.19)	0.022
Dyslipidemia	-3.83 (-10.64 to 2.99)	0.269	-2.20 (-10.45 to 6.05)	0.597	-3.31 (-12.08 to 5.46)	0.454
Hypertension	-3.16 (-11.73 to 5.42)	0.467	-1.67 (-15.43 to 12.09)	0.810	-1.13 (-15.81 to 13.54)	0.878

¹These include pre-transplant myocardial infarction, cerebrovascular events, peripheral vascular disease.

CCI: Comprehensive complication index; CDC: Clavien-Dindo classification; BMI: Body mass index.