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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transplant. Dec 18, 2025; 15(4): 104399
Published online Dec 18, 2025. doi: 10.5500/wjt.v15.i4.104399
Published online Dec 18, 2025. doi: 10.5500/wjt.v15.i4.104399
Comparison of Clavien–Dindo classification and comprehensive complication index in patients undergoing simultaneous pancreas-kidney transplantation
Alessandro Parente, Kevin Verhoeff, Braulio A Marfil-Garza, Norberto Sanchez-Fernandez, Blaire L Anderson, David L Bigam, AM James Shapiro, Khaled Z Dajani, Division of Transplantation, Department of Surgery, Faculty of Medicine and Dentistry, University of Alberta Hospital, Edmonton T6G 2B7, Alberta, Canada
Alessandro Parente, Kevin Verhoeff, Braulio A Marfil-Garza, AM James Shapiro, Alberta Diabetes Institute, University of Alberta Hospital, Edmonton T6G 2B7, Alberta, Canada
Braulio A Marfil-Garza, Tecnologico de Monterrey, The Institute for Obesity Research, Monterrey CP 64710, Mexico
Author contributions: Parente A, Verhoeff K and Dajani KZ wrote the manuscript, participated in the conception and design of the study and were involved in the acquisition, analysis, or interpretation of data; Parente A, Verhoeff K, Marfil-Garza BA, Sanchez-Fernandez N, Anderson BL, Bigam DL, Shapiro AMJ, and Dajani KZ critically reviewed and provided final approval of the manuscript; and all authors were responsible for the decision to submit the manuscript for publication.
Institutional review board statement: This study was approved by the Medical Ethics Committee of University of Alberta Hospital, approval No. Pro00087040.
Informed consent statement: This is a retrospective cohort study and informed consent of patients was not required as it involved the review of anonymized data.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The authors confirm that the data supporting the findings of this study are available within the article. Raw data that support the findings of this study are available from the corresponding author, upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Alessandro Parente, MD, PhD, Department of Surgery, Division of Transplantation, University of Alberta Hospital, 8440 112 St NW, Edmonton T6G 2B7, Alberta, Canada. aleparen@gmail.com
Received: December 19, 2024
Revised: March 23, 2025
Accepted: April 11, 2025
Published online: December 18, 2025
Processing time: 334 Days and 9.5 Hours
Revised: March 23, 2025
Accepted: April 11, 2025
Published online: December 18, 2025
Processing time: 334 Days and 9.5 Hours
Core Tip
Core Tip: This is a retrospective single-center study to compare Clavien-Dindo classification and comprehensive complication index (CCI) in predicting outcomes after simultaneous pancreas-kidney transplantation. CCI has shown a stronger correlation with length of hospital stay when compared to Clavien-Dindo classification due to its cumulative nature. We advocate the utilization of CCI for future studies as it represents a more sensitive tool to better evaluate the overall burden of postoperative complications in patients undergoing simultaneous pancreas-kidney transplantation.