Haemodynamic management in brain death donors: Influence of aetiology of brain death

doi:10.5500/wjt.v13.i4.183

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World Journal of Transplantation

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2220-3230

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Transplant. Jun 18, 2023; 13(4): 183-189
Published online Jun 18, 2023. doi: 10.5500/wjt.v13.i4.183

Table 1 Study population, n (%)

	Stroke	Traumatic brain injury	Postanoxic encelophaphy
Number	71	48	19
Age (yr, mean ± SD)	79 ± 14	68 ± 20	59 ± 19	0.0007^a
Males	34 (48)	31 (65)	10 (53)	0.197^b
Risk factors				0.673^b
Hypertension	51	10	24
Diabetes	24	9	16
Heart disease	6	2	5
Refusals to donation	13	10	2	0.613^b
Utilized donors (n)	54	35	15	0.808^b
Utilization rate (%)	93	92	89

^aOne way analysis of variance.

^bχ².

Table 2 Haemodynamic data, n (%)

	Stroke	Traumatic brain injury	Postanoxic encephalopathy
Number	71 (51)	48 (35)	19 (14)
ICU admission
SBP (mmHg), mean ± SD	112 ± 44	123 ± 34	98 ± 33	0.002^a
DBP (mmHg), mean ± SD	74 ± 21	74 ± 18	77 ± 22	0.001^a
HR (bpm), mean ± SD	75 ± 22	77 ± 34	82 ± 35	0.015^a
CVP (cmH₂O), mean ± SD	10 ± 3	11 ± 4	10 ± 3	0.819^a
Norepinephrine	31 (44)	29 (60)	14 (74)	0.03^b
Other vasoactive drugs	5 (7)	9 (18)	6 (32)	0.015^b
Urine output, median (IQR)	200 (125-393)	261 (124-408)	287 (186-440)	0.279^a
Lactate (mg/dL), median (IQR)	1.5 (1-2.6)	2.1 (1.3-3.1)	1.8 (0.8-4.6)	0.033^a
Time 1
SBP (mmHg), mean ± SD	123 ± 19	125 ± 23	122 ± 21	0.818^a
DBP (mmHg), mean ± SD	63 ± 13	65 ± 14	68 ± 17	0.497^a
HR (bpm), mean ± SD	86 ± 16	92 ± 17	94 ± 22	0.037^a
Norepinephrine	56 (78)	43 (89)	18 (95)	0.120^b
CVP (cmH₂O), mean ± SD	10 ± 3	11 ± 5	12 ± 7	0.001^a
Other vasoactive drugs	7 (9.8)	10 (20)	5 (26)	0.113^b
Urine output, median (IQR)	113 (57-210)	115 (85-285)	110 (65 220)	0.374^a
Lactate (mg/dL), median (IQR)	1.2 (0.9-1.7)	1.4 (1-3.1)	1.7 (1.3-3.1)	0.006^a
Time 2
SBP (mmHg), mean ± SD	133 ± 25	131 ± 22	126 ± 27	0.510^a
DBP (mmHg), mean ± SD	66 ± 14	65 ± 12	70 ± 17	0.784^a
HR (bpm), mean ± SD	94 ± 19	95 ± 15	99 ± 25	0.760^a
Norepinephrine	57	43	18	0.172^b
Other vasoactive drugs	8 (11)	6 (12)	5 (26)	0.227^b
CVP (cmH₂O), mean ± SD	10 ± 4	12 ± 4 (12)	13 ± 4	0.040^a
Urine output, median (IQR)	143 (79-240)	160 (95-250)	200 (92-250)	0.785^a

^aOne-way analysis of variance.

^bχ².

IQR: Interquartile range; ICU: Intensive care unit; CVP: Central venous pressure, SBP: Systolic blood pressure; DBP: Diastolic blood pressure; HR: Heart rate.

Citation: Lazzeri C, Bonizzoli M, Batacchi S, Guetti C, Vessella W, Valletta A, Ottaviano A, Peris A. Haemodynamic management in brain death donors: Influence of aetiology of brain death. World J Transplant 2023; 13(4): 183-189
URL: https://www.wjgnet.com/2220-3230/full/v13/i4/183.htm
DOI: https://dx.doi.org/10.5500/wjt.v13.i4.183