1400W reduces ischemia reperfusion injury in an ex-vivo porcine model of the donation after circulatory death kidney donor

Figure 1 Mean renal blood flow over 3 h of reperfusion in the Control and 1400W groups. Area under the curve (AUC), P = 0.999 (A); Mean intrarenal resistance over 3 h of reperfusion in the Control and 1400W groups, AUC, P = 0.234 (B). Mann Whitney U-test. RBF: Mean renal blood flow.

Figure 2 Mean creatinine clearance over 3 h of reperfusion in the Control and 1400W groups. (P = 0.026 and 0.009 after 1 and 2 h, respectively) (A); Mean serum creatinine levels over 3 h of reperfusion in the Control and 1400W groups, P > 0.050 between groups (B). Mann Whitney U-test.

Figure 3 Urinary levels of 8-isoprostane after 3 h of reperfusion in the Control and 1400W groups (^aP = 0. 041 between groups) (A); Levels of total nitric oxide in the urine after 1 and 3 h of reperfusion Control and 1400W groups (^bP = 0.002 and 0.002, respectively) between groups (B); Myeloperoxidase score after 3 h of reperfusion in the Control and 1400W (^bP = 0.002) between groups (C). Mann Whitney U-test, scored by counting the number of positive cells in 20 fields (× 400). MPO: Myeloperoxidase.