De Pietri L, Bianchini M, Rompianesi G, Bertellini E, Begliomini B. Thromboelastographic reference ranges for a cirrhotic patient population undergoing liver transplantation. World J Transplant 2016; 6(3): 583-593 [PMID: 27683637 DOI: 10.5500/wjt.v6.i3.583]
Corresponding Author of This Article
Lesley De Pietri, MD, Division of Anaesthesiology and Intensive Care Unit, Department of Cardiology, Thoracic and Vascular Surgery, Critical Care Medicine, Arcispedale Santa Maria Nuova, IRCCS, Viale Risorgimento 80, 42123 Reggio Emilia, Italy. lesley.depietri@asmn.re.it
Research Domain of This Article
Anesthesiology
Article-Type of This Article
Retrospective Cohort Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Transplant. Sep 24, 2016; 6(3): 583-593 Published online Sep 24, 2016. doi: 10.5500/wjt.v6.i3.583
Thromboelastographic reference ranges for a cirrhotic patient population undergoing liver transplantation
Lesley De Pietri, Marcello Bianchini, Gianluca Rompianesi, Elisabetta Bertellini, Bruno Begliomini
Lesley De Pietri, Division of Anaesthesiology and Intensive Care Unit, Department of Cardiology, Thoracic and Vascular Surgery, Critical Care Medicine, Arcispedale Santa Maria Nuova, 42123 Reggio Emilia, Italy
Marcello Bianchini, Gastroenterology Unit, Department of Internal Medicine, Azienda Ospedaliero, Universitaria di Modena, 41100 Modena, Italy
Gianluca Rompianesi, Liver and Multivisceral Transplant Center, Azienda Ospedaliero-Universitaria di Modena, 41100 Modena, Italy
Elisabetta Bertellini, Bruno Begliomini, Division of Anaesthesiology and Intensive Care Unit, Department of Surgery, Azienda Ospedaliero, Universitaria di Modena, 41100 Modena, Italy
Author contributions: De Pietri L conceived the study and drafted the article; Bianchini M contributed to data analysis and attests the integrity of the original data and the analysis; Rompianesi G contributed to data analysis and attests the integrity of the original data and the analysis; Bertellini E participated in the acquisition of the data and Begliomini B revised the article critically for important intellectual content.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of Azienda Ospedaliera-Universitaria, Modena (139/14 Trigger) and was conducted in accordance with provisions of the Declaration of Helsinki and Good Clinical Practice guidelines.
Informed consent statement: All patients or their legal guardian, provided a written informed consent prior to study enrolment.
Conflict-of-interest statement: All the Authors have no conflict of interest related to the manuscript.
Data sharing statement: The original anonymous dataset is available on request from the corresponding author at lesley.depietri@yahoo.it.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Lesley De Pietri, MD, Division of Anaesthesiology and Intensive Care Unit, Department of Cardiology, Thoracic and Vascular Surgery, Critical Care Medicine, Arcispedale Santa Maria Nuova, IRCCS, Viale Risorgimento 80, 42123 Reggio Emilia, Italy. lesley.depietri@asmn.re.it
Telephone: +39-059-4225864 Fax: +39-059-4224100
Received: April 11, 2016 Peer-review started: April 12, 2016 First decision: June 12, 2016 Revised: June 21, 2016 Accepted: August 15, 2016 Article in press: August 16, 2016 Published online: September 24, 2016 Processing time: 165 Days and 21.2 Hours
Core Tip
Core tip: Thromboelastography provides a more comprehensive coagulation assessment than routine tests in cirrhotic patients. We evaluated the baseline thromboelastography (TEG) tracing and preoperative laboratory tests of cirrhotic patients undergoing liver transplant (LT) to generate a reliable picture of their coagulation profile. We also studied how TEG value distribution in cirrhotic patients could be modified by gender, age, model for end-stage liver disease score and liver disease characteristics. End-stage liver disease is associated with considerable changes in TEG variables, which should be allowed for when interpreting TEG traces in cirrhotic patients. TEG reference values derived from a healthy population could be misleading in the management of cirrhotic patients during LT.
