©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transplant. Jun 24, 2016; 6(2): 291-305
Published online Jun 24, 2016. doi: 10.5500/wjt.v6.i2.291
Published online Jun 24, 2016. doi: 10.5500/wjt.v6.i2.291
Massive haemorrhage in liver transplantation: Consequences, prediction and management
Stuart Cleland, Carlos Corredor, Jia Jia Ye, Coimbatore Srinivas, Stuart A McCluskey, Department of Anesthesia and Pain Management, Toronto General Hospital, University Health Network, Toronto, ON M5G 2C4, Canada
Stuart Cleland, Carlos Corredor, Jia Jia Ye, Coimbatore Srinivas, Stuart A McCluskey, Department of Anesthesia, University of Toronto, Toronto, ON M5S 1A1, Canada
Author contributions: All authors contributed to the conception and design of the review as well as giving final approval of the final version; Cleland S, Corredor C and Ye JJ performed the literature review as well as drafting of initial version and subsequent revisions up to final version; Srinivas C and McCluskey SA provided critical revision and editing of initial and all subsequent versions.
Supported by Department of Anesthesia and Pain Management academic program support.
Conflict-of-interest statement: No potential conflicts of interest. No financial support.
Correspondence to: Stuart A McCluskey, MD, PHD, FRCPC, Department of Anesthesia and Pain Management, Toronto General Hospital, University Health Network, 200 Elizabeth Street, EN3-438, Toronto, ON M5G 2C4, Canada. stuart.mccluskey@uhn.ca
Telephone: +1-416-3405164 Fax: +1-416-3403698
Received: November 10, 2015
Peer-review started: November 12, 2015
First decision: February 2, 2016
Revised: March 22, 2016
Accepted: April 7, 2016
Article in press: April 11, 2016
Published online: June 24, 2016
Processing time: 225 Days and 16.1 Hours
Peer-review started: November 12, 2015
First decision: February 2, 2016
Revised: March 22, 2016
Accepted: April 7, 2016
Article in press: April 11, 2016
Published online: June 24, 2016
Processing time: 225 Days and 16.1 Hours
Core Tip
Core tip: The management of bleeding during liver transplantation requires an understanding of the unique coagulopathy of liver failure and the ability to recognize the risk factors for massive transfusion. By avoiding massive haemorrhage and transfusion, patients’ outcomes after transplantation are likely to benefit.