Wiesen P, Massion PB, Joris J, Detry O, Damas P. Incidence and risk factors for early renal dysfunction after liver transplantation. World J Transplant 2016; 6(1): 220-232 [PMID: 27011921 DOI: 10.5500/wjt.v6.i1.220]
Corresponding Author of This Article
Dr. Patricia Wiesen, Department of General Intensive Care, University Hospital of Liege, Domaine universitaire du Sart Tilman B35, B-4000 Liege, Belgium. p.wiesen@chu.ulg.ac.be
Research Domain of This Article
Transplantation
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Share the Article
Wiesen P, Massion PB, Joris J, Detry O, Damas P. Incidence and risk factors for early renal dysfunction after liver transplantation. World J Transplant 2016; 6(1): 220-232 [PMID: 27011921 DOI: 10.5500/wjt.v6.i1.220]
World J Transplant. Mar 24, 2016; 6(1): 220-232 Published online Mar 24, 2016. doi: 10.5500/wjt.v6.i1.220
Incidence and risk factors for early renal dysfunction after liver transplantation
Patricia Wiesen, Paul B Massion, Jean Joris, Olivier Detry, Pierre Damas
Patricia Wiesen, Paul B Massion, Pierre Damas, Department of General Intensive Care, University Hospital of Liege, B-4000 Liege, Belgium
Jean Joris, Department of Anaesthesiology and Intensive Care Medicine, University Hospital of Liege, B-4000 Liege, Belgium
Olivier Detry, Department of Abdominal Surgery and Transplantation, CHU Liege, University of Liege (CHU ULg), B-4000 Liege, Belgium
Author contributions: Wiesen P performed the literature review and wrote the manuscript; Massion PB and Damas P participated in article conception; Joris J and Detry O constituted part of the team involved in the care of liver transplanted patients.
Institutional review board statement: The study was reviewed and approved by the University Hospital of Liege Institutional Review Board.
Informed consent statement: We did not initially claim an informed consent from the patients. Indeed, according to the institutional ethics committee’s opinion, no informed consent was required in the frame of this retrospective study. However, we phoned all alive patients with available coordinates and obtained their oral informed consent.
Conflict-of-interest statement: The authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements) in the subject matter or materials discussed in this manuscript. This statement is signed by all the authors to indicate agreement that the above information is true and correct.
Data sharing statement: No additional data are available.
Correspondence to: Dr. Patricia Wiesen, Department of General Intensive Care, University Hospital of Liege, Domaine universitaire du Sart Tilman B35, B-4000 Liege, Belgium. p.wiesen@chu.ulg.ac.be
Telephone: +32-4-3667495 Fax: +32-4-3668898
Received: August 12, 2015 Peer-review started: August 13, 2015 First decision: September 28, 2015 Revised: November 27, 2015 Accepted: December 17, 2015 Article in press: December 18, 2015 Published online: March 24, 2016 Processing time: 219 Days and 14.3 Hours
Core Tip
Core tip: One hundred and eighty-seven liver transplantations performed between 2006 and 2012 were retrospectively analyzed. Patients were classified into four groups according to their highest creatinine plasma level during the first postoperative week relying on sequential organ failure assessment renal classification. Perioperative parameters were recorded as risk factors. Univariate and multivariate analysis were performed. Fifty-eight percent of recipients experienced some degree of early postoperative renal dysfunction. The multivariate analysis showed that body mass index, preoperative creatinine level, use of vasopressor, hemostatic drug, postoperative bilirubin peak level and postoperative hemoglobin minimum level but not the donor status (cardiac dead or brain dead donor) were independent predictors of post-transplantation early renal dysfunction.
