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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transplant. Dec 24, 2015; 5(4): 292-299
Published online Dec 24, 2015. doi: 10.5500/wjt.v5.i4.292
Published online Dec 24, 2015. doi: 10.5500/wjt.v5.i4.292
Clinical and pathological features of kidney transplant patients with concurrent polyomavirus nephropathy and rejection-associated endarteritis
Stephanie M McGregor, Anthony Chang, Department of Pathology, University of Chicago Hospitals, Chicago, IL 60637, United States
W James Chon, Department of Medicine, Section of Nephrology, University of Chicago Hospitals, Chicago, IL 60637, United States
Lisa Kim, Hawaii Pathologists’ Laboratory, Honolulu, HI 96813, United States
Shane M Meehan, Sharp Memorial Hospital, San Diego, CA 92123, United States
Author contributions: All authors contributed to data collection, analysis and writing of the manuscript.
Institutional review board statement: This study was reviewed and approved by the Biological Sciences Division/University of Chicago Medical Center Institutional Review Board at the University of Chicago (IRB14-0052).
Informed consent statement: Patients were not required to give informed consent to the study due the retrospective nature of the study. A waiver of consent is included in the IRB protocol.
Conflict-of-interest statement: We have no financial relationships or conflicts of interest to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Shane M Meehan, MB, BCh, Pathologist, Sharp Memorial Hospital, 7901 Frost Street, San Diego, CA 92123, United States. smmeehan414@gmail.com
Telephone: +1-858-9393660 Fax: +1-858-9393647
Received: June 10, 2015
Peer-review started: June 11, 2015
First decision: August 25, 2015
Revised: October 14, 2015
Accepted: November 10, 2015
Article in press: November 11, 2015
Published online: December 24, 2015
Processing time: 196 Days and 1.8 Hours
Peer-review started: June 11, 2015
First decision: August 25, 2015
Revised: October 14, 2015
Accepted: November 10, 2015
Article in press: November 11, 2015
Published online: December 24, 2015
Processing time: 196 Days and 1.8 Hours
Core Tip
Core tip: Here we report the clinical and pathologic features of 7 cases of concurrent polyomavirus nephropathy (PVN) and endarteritis identified out of 94 renal allograft recipients who developed PVN over an 11-year period (7.4%). These cases arose both in the setting of a prior reduction in immunosuppression (IS) and without such a change. Therefore, concurrent PVN and endarteritis appears more frequent than currently reported in the literature and may occur with or without prior reduction of IS.