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World J Transplant. Jun 18, 2026; 16(2): 118249
Published online Jun 18, 2026. doi: 10.5500/wjt.v16.i2.118249
Published online Jun 18, 2026. doi: 10.5500/wjt.v16.i2.118249
Efficacy and safety of low-dose everolimus and tacrolimus in kidney transplant recipients: A retrospective study
Dilip Kumar Pahari, Department of Nephrology, Medica Superspeciality Hospital, Kolkata 700099, West Bengal, India
Hirak Pahari, Department of Liver Transplant and Hepatobiliary Surgery, Medica Super
Co-first authors: Dilip Kumar Pahari and Hirak Pahari.
Author contributions: Pahari DK contributed to the concept design, methodology, data collection and writing of the paper; Pahari H contributed to data collection, analysis and writing and submission of the paper.
Institutional review board statement: Exemption from formal IRB review has been approved, as this is a survey of different treatment teams with no direct patient contact and no identifiable patient information.
Informed consent statement: Since the data is also retrospective and the study is observational in nature, informed consent can be waived in this respect.
Conflict-of-interest statement: All authors declare that they have no conflict of interest to disclose.
Data sharing statement: The data of this study is available on request from the corresponding author or first author.
Corresponding author: Hirak Pahari, MD, Department of Liver Transplant and Hepatobiliary Surgery, Medica Superspeciality Hospital, Mukundapur, Kolkata 700099, West Bengal, India. hirak.pahari@gmail.com
Received: December 28, 2025
Revised: March 15, 2026
Accepted: April 1, 2026
Published online: June 18, 2026
Processing time: 152 Days and 15.7 Hours
Revised: March 15, 2026
Accepted: April 1, 2026
Published online: June 18, 2026
Processing time: 152 Days and 15.7 Hours
Core Tip
Core Tip: The use of combination of low dose tacrolimus and everolimus is not common in kidney transplant recipients. We show in our study that the combination therapy with everolimus (low dose) + tacrolimus (Tac) (low dose) as compared to mycophenolate mofetil + Tac is found to be superior in terms of lower incidence of side effects and stable serum creatinine levels over long-term follow-up.