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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transplant. Dec 18, 2025; 15(4): 108728
Published online Dec 18, 2025. doi: 10.5500/wjt.v15.i4.108728
Published online Dec 18, 2025. doi: 10.5500/wjt.v15.i4.108728
Clinical impact of early graft function in kidney transplant recipients on long-term dialysis: A retrospective cohort study
Hisao Shimada, Department of Urology, Asakayama General Hospital, Sakai 590-0018, Japan
Tomoaki Iwai, Junji Uchida, Department of Urology, Graduate School of Medicine, Osaka Metropolitan University, Osaka 545-8585, Japan
Author contributions: Shimada H and Uchida J were responsible for the idea; Shimada H, Iwai T and Uchida J contributed to literature search, the intellectual content conception, write the manuscript, and prepared figures and tables.
Institutional review board statement: Approved for this study was obtained from the Ethics Committee of Graduate School of Medicine, Osaka Metropolitan University (No. 3604).
Informed consent statement: Patient consent was verified not by written informed consent but by opt-out consent, providing the patients with information on our research plan including the purpose, required individual data, and duration of research on our hospital website.
Conflict-of-interest statement: All the authors reported no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement checklist of items, and the manuscript was prepared and revised according to the STROBE statement-checklist of items.
Data sharing statement: Data are available upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Tomoaki Iwai, MD, PhD, Department of Urology, Graduate School of Medicine, Osaka Metropolitan University, 1-4-3, Asahimachi, Abeno-ku, Osaka 545-8585, Japan. iwai@omu.ac.jp
Received: April 22, 2025
Revised: May 15, 2025
Accepted: August 25, 2025
Published online: December 18, 2025
Processing time: 211 Days and 19.2 Hours
Revised: May 15, 2025
Accepted: August 25, 2025
Published online: December 18, 2025
Processing time: 211 Days and 19.2 Hours
Core Tip
Core Tip: This retrospective cohort study investigated the impact of dialysis duration and early graft function on kidney transplant outcomes. Among 255 recipients, no significant differences were found between long- and short-term dialysis groups in key clinical variables. Multivariate analysis identified age, post-transplant cardiovascular events, and best serum creatinine within three months as independent predictors of mortality. In contrast, dialysis duration was not associated with post-transplant survival. These findings highlight that early graft function may be more critical than dialysis duration in determining long-term transplant outcomes.