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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transplant. Dec 18, 2025; 15(4): 104111
Published online Dec 18, 2025. doi: 10.5500/wjt.v15.i4.104111
Published online Dec 18, 2025. doi: 10.5500/wjt.v15.i4.104111
Utilization of normothermic machine perfusion in pediatric liver transplantation: Three case reports
Christine S Hwang, Andrew D Shubin, Christine Johansen, Jigesh A Shah, Parsia A Vagefi, Madhukar S Patel, Division of Surgical Transplantation, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States
Christine S Hwang, Andrew D Shubin, Christine Johansen, Jigesh A Shah, Parsia A Vagefi, Madhukar S Patel, Division of Pediatric Transplantation, Children’s Medical Center, Dallas, TX 75235, United States
Amal Aqul, Division of Pediatric Gastroenterology, Children’s Medical Center, Dallas, TX 75235, United States
Jorge A Sanchez-Vivaldi, Programa Transplante Hígado Adulto Y Pedíatrico, Auxilio Mutuo, San Juan, PR 00917, United States
Kayla D Colvill, Division of Transplant Surgery, Texas Health Resources-Fort Worth, Dallas, TX 76104, United States
Malcolm P MacConmara, Abdominal Transplant, Transmedics inc, Andover, MA 01810, United States
Yash Kadakia, Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, United States
Steven I Hanish, Division of Transplant Surgery, Medical University of South Carolina, Charleston, SC 29425, United States
Author contributions: Hwang CS contributed to gathered, organized, and analyzed the data; Shubin AD, Aqul A, Sanchez-Vivaldi JA contributed to Particiapted in writing and reviewing the manuscript; Colvill K, Shah JA, Hanish S, and Vagefi PA contributed to Participated in reviewing the manuscript; MacConmara M contributed to participated in gathering, organizing, and performing data analysis; Kadakia Y contributed to participated in analyzing data; Patel MS contributed to participated in gathering, organizing, and performing data analysis; Hwang CS, MacConmara M, Kadakia Y, Johansen C, and Patel MS contributed to writing the manuscript.
Informed consent statement: All patients and families gave consent to have their information be part of this manuscript.
Conflict-of-interest statement: Madhukar S. Patel is supported as the Dedman Scholar of Clinical Care at UT Southwestern Medical Center. The funder had no role in design and conduct of the study; collection, management, analysis, and interpretation of the data; or preparation of the manuscript. All authors declare that they have no competing interests.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Christine S Hwang, MD, Associate Professor, Division of Surgical Transplantation, University of Texas Southwestern Medical Center, 6201 Harry Hines Blvd., Dallas, TX 75390, United States. christine.hwang@utsouthwestern.edu
Received: December 13, 2024
Revised: April 13, 2025
Accepted: May 10, 2025
Published online: December 18, 2025
Processing time: 341 Days and 19.3 Hours
Revised: April 13, 2025
Accepted: May 10, 2025
Published online: December 18, 2025
Processing time: 341 Days and 19.3 Hours
Core Tip
Core Tip: We report the first published use of normothermic machine perfusion in pediatric liver transplant recipients.