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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transplant. Mar 18, 2025; 15(1): 98003
Published online Mar 18, 2025. doi: 10.5500/wjt.v15.i1.98003
Published online Mar 18, 2025. doi: 10.5500/wjt.v15.i1.98003
Efficacy of antimicrobials in preventing resistance in solid organ transplant recipients: A systematic review of clinical trials
Carlos M Ardila, Department of Basic Sciences Faculty of Dentistry, Biomedical Stomatology Research Group, Universidad de Antioquia U de A, Medellín 0057, Colombia
Carlos M Ardila, Department of Postdoctoral Program, CIFE University Center, Cuernavaca 62330, Morelos, Mexico
Pradeep K Yadalam, Department of Periodontics, Saveetha Dental College, Saveetha Institute of Medical and Health, SIMATS, Saveetha University, Chennai 600077, Tamil Nadu, India
Jaime Ramírez-Arbelaez, Department of Transplantation, Hospital San Vicente Fundación, Rionegro 054047, Colombia
Author contributions: Ardila CM performed the conceptualization, data curation, data analysis, manuscript writing, and revision of the manuscript; Yadalam PK performed the data curation, data analysis, and revision of the manuscript; Ramírez-Arbeláez J performed the data curation, data analysis, and revision of the manuscript.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Carlos M Ardila, Doctor, MSc, PhD, Academic Research, Associate Professor, Department of Basic Sciences, Biomedical Stomatology Research Group, Universidad de Antioquia U de A, Calle 70 52-21, Medellín 0057, Colombia.
Received: June 14, 2024
Revised: September 26, 2024
Accepted: October 28, 2024
Published online: March 18, 2025
Processing time: 165 Days and 17 Hours
Revised: September 26, 2024
Accepted: October 28, 2024
Published online: March 18, 2025
Processing time: 165 Days and 17 Hours
Core Tip
Core Tip: This systematic review evaluates the efficacy of antimicrobial agents in preventing resistance among solid organ transplant recipients. Despite varying results across studies, maribavir and valganciclovir showed promise in reducing resistance rates compared to controls. However, overall, significant proportions of antimicrobial-resistant microorganisms were observed post-intervention, highlighting the urgent need for further high-quality randomized clinical trials to validate these findings and improve outcomes in organ transplantation.