Retrospective Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transplant. Jun 18, 2024; 14(2): 89825
Published online Jun 18, 2024. doi: 10.5500/wjt.v14.i2.89825
Does the use of double hormone replacement therapy for trauma patient organ donors improve organ recovery for transplant
Eden M Gallegos, Tanner Reed, Paige Deville, Blake Platt, Claudia Leonardi, Lillian Bellfi, Jessica Dufrene, Saad Chaudhary, John Hunt, Lance Stuke, Patrick Greiffenstein, Jonathan Schoen, Alan Marr, Anil Paramesh, Alison A Smith
Eden M Gallegos, Department of Physiology, Louisiana State University Health Sciences Center New Orleans, New Orleans, LA 70124, United States
Tanner Reed, Saad Chaudhary, Department of Medicine, Louisiana State University Health Sciences Center New Orleans, New Orleans, LA 70112, United States
Paige Deville, Lillian Bellfi, John Hunt, Lance Stuke, Patrick Greiffenstein, Jonathan Schoen, Alan Marr, Alison A Smith, Department of Surgery, Louisiana State University Health Sciences Center New Orleans, New Orleans, LA 70112, United States
Blake Platt, Department of Trauma Surgery, Tacoma General Hospital, Tacoma 98405, United States
Claudia Leonardi, Department of Public Health, Louisiana State University Health Sciences Center New Orleans, New Orleans, LA 70112, United States
Jessica Dufrene, Department of Donation Services, Louisiana Organ Procurement Agency, Covington, LA 70433, United States
Anil Paramesh, Department of Surgery, Tulane Transplant Institute, Tulane University School of Medicine, New Orleans, LA 70112, United States
Author contributions: Gallegos EM wrote the first draft and revisions of the manuscript; Gallegos EM, Smith AA, Reed T, Paramesh A, Bellfi L, and Dufrene J contributed to the research design of this manuscript; Gallegos EM, Reed T, and Chaudhary S contributed to the performance of the research; Gallegos EM, Deville P, Platt B, Leonardi C, and Smith AA contributed to data analysis; Paramesh A, Smith AA, Deville P, Platt B, Leonardi C, Hunt J, Stuke L, Greiffenstein P, Schoen J, and Marr A provided critical revisions of the manuscript.
Institutional review board statement: The Louisiana State University Health Sciences Center-New Orleans Institutional Review Board approved this study (#1966), and a waiver of informed consent was obtained.
Informed consent statement: Informed consent was waived by the ethics committee because this was an observational retrospective study.
Conflict-of-interest statement: Dr. Smith reports personal fees from Prytime Medical, personal fees from Aroa Biosurgery, grants from 3M, grants from MiMedX, and grants from Dynocardia outside the submitted work.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Alison A Smith, FACS, MD, PhD, Assistant Professor, Surgeon, Department of Surgery, Louisiana State University Health Sciences Center New Orleans, 2021 Perdido Street, 8th Floor, New Orleans, LA 70112, United States. asmi60@lsuhsc.edu
Received: November 27, 2023
Revised: February 16, 2024
Accepted: April 16, 2024
Published online: June 18, 2024
Processing time: 200 Days and 2.7 Hours
Core Tip

Core Tip: The present study considers the impact of combination endocrine management on the number of solid organs donated in brain-dead organ donors. Specifically, we focused on the use of steroids alone or steroids and levothyroxine in organ donors of the trauma patient population from a single level 1 trauma center. We showed a significant association between a high yield of organs donated per donor and the use of combination hormone replacement therapy as compared to steroids alone. These data complement published literature on combination endocrine management and highlight the role of levothyroxine on the number of organs recovered per organ donor.