Meta-Analysis
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transplant. Jan 18, 2023; 13(1): 10-24
Published online Jan 18, 2023. doi: 10.5500/wjt.v13.i1.10
Outcomes of total pancreatectomy with islet autotransplantation: A systematic review and meta-analysis
Shrouq Khazaaleh, Sumbal Babar, Mohammad Alomari, Zaid Imam, Pravallika Chadalavada, Adalberto Jose Gonzalez, Bara El Kurdi
Shrouq Khazaaleh, Department of Internal Medicine, Cleveland Clinic Fairview Hospital, Cleveland, OH 44126, United States
Sumbal Babar, Department of Internal Medicine-Infectious Diseases Division, University of Texas Health Science Center at San Antonio, San Antonio, TX 78249, United States
Mohammad Alomari, Department of Gastroenterology and Hepatology, Cleveland Clinic Florida, Weston, FI 33324, United States
Zaid Imam, Department of Gastroenterology and Hepatology, William Beaumont Hospital, Royal Oak, MI 48073, United States
Pravallika Chadalavada, Adalberto Jose Gonzalez, Department of Gastroenterology and Hepatology, Cleveland Clinic Florida, Weston, FI 33331, United States
Bara El Kurdi, Department of Gastroenterology and Hepatology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78249, United States
Author contributions: Khazaaleh S and Babar S contributed to study design, data interpretation, manuscript writing, and administrative support; Alomari M contributed to literature review and data collection; Imam Z and Chadalavada AJ contributed to data assembly, and data analysis including statistical analysis and creating tables and graphs; Kurdi BE contributed to supervisory role, data interpretation and primary investigator; all authors contributed to the paper writing, and manuscript revision and approved the submitted version of this manuscript.
Conflict-of-interest statement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bara El Kurdi, MD, Academic Fellow, Department of Gastroenterology and Hepatology, University of Texas Health science center at San Antonio, 1 UTSA Circle, San Antonio, TX 78249, United States. baraabayern@gmail.com
Received: October 7, 2022
Peer-review started: October 7, 2022
First decision: November 14, 2022
Revised: November 24, 2022
Accepted: December 23, 2022
Article in press: December 23, 2022
Published online: January 18, 2023
Processing time: 97 Days and 7.1 Hours
Core Tip

Core Tip: Surgical intervention is required for the management of debilitating and refractory abdominal pain in chronic pancreatitis (CP) patients failing medical therapy. Since first introduced in 1978, total pancreatectomy with islet autotransplantation (TPIAT) has shown promising results in CP patients, but the literature remains limited. This systematic review and meta-analysis found that TPIAT provided acceptable levels of pain relief and insulin independence.