Opinion Review
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transplant. Jun 18, 2022; 12(6): 112-119
Published online Jun 18, 2022. doi: 10.5500/wjt.v12.i6.112
Tolerance protocol of living kidney transplant for developing countries through basic strategy of lymphocyte depletion
Sufi M Suhail
Sufi M Suhail, Department of Renal Medicine, Singapore General Hospital, Singapore 169856, Singapore
Sufi M Suhail, Department of Clinical Research, Duke-NUS Graduate Medical School, Singapore 169856, Singapore
Author contributions: Suhail SM has contributed to the opinion and conclusion of this opinion review solely. He based this opinion review based on his recent publication with a view to confer generalizability of the protocol for the greater interest of ESKD patients of developing countries with an intention to attracting relevant transplant organizations there, where the ESKD burden is high and the availability kidney transplant program is low. The planning of contents of the review and the designs of the figures were done by the author based on the existing information in transplant medicine.
Conflict-of-interest statement: This opinion review is done based on our recent publication with a view to confer generalizability of the protocol for the greater interest of ESKD patients of developing countries.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sufi M Suhail, FRCP, MBBS, MRCP, Assistant Professor, Department of Renal Medicine, Singapore General Hospital, Block 6, Level 6, Outram Road, Singapore 169856, Singapore. grmsms@sgh.com.sg
Received: May 17, 2021
Peer-review started: May 17, 2021
First decision: June 17, 2021
Revised: July 28, 2021
Accepted: May 5, 2022
Article in press: May 5, 2022
Published online: June 18, 2022
Processing time: 394 Days and 0.6 Hours
Core Tip

Core Tip: In this opinion review that is based on our recent publication, the core tip concentrates on achieving a partial or prope tolerance in renal allograft through sequential B and T lymphocyte depletion in an approved and in-practice strategy, for living related and low risk kidney transplantation. The allograft would require a half dose dual immunosuppressive therapy subsequently.