©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transplant. Aug 18, 2021; 11(8): 344-355
Published online Aug 18, 2021. doi: 10.5500/wjt.v11.i8.344
Published online Aug 18, 2021. doi: 10.5500/wjt.v11.i8.344
May mesenchymal stem cell transplantation be a solution for COVID-19 induced cytokine storm?
Hüseyin Sütlüoğlu, Faculty of Medicine, Sakarya University, Adapazarı 54100, Sakarya, Turkey
Öner Özdemir, Division of Pediatric Allergy and Immunology, Sakarya University Medical Faculty, Adapazarı 54100, Sakarya, Turkey
Author contributions: Sütlüoğlu H performed the writing, created the figures and tables; Özdemir Ö designed the outline, and coordinated the writing of the paper.
Conflict-of-interest statement: The authors declare no conflict of interest regarding the publication of this paper.
Corresponding author: Öner Özdemir, MD, Full Professor, Division of Pediatric Allergy and Immunology, Sakarya University Medical Faculty, Adnan Menderes Cad., Adapazarı 54100, Sakarya, Turkey. ozdemir_oner@hotmail.com
Received: February 22, 2021
Peer-review started: February 22, 2021
First decision: May 5, 2021
Revised: June 16, 2021
Accepted: August 10, 2021
Article in press: August 10, 2021
Published online: August 18, 2021
Processing time: 171 Days and 3.4 Hours
Peer-review started: February 22, 2021
First decision: May 5, 2021
Revised: June 16, 2021
Accepted: August 10, 2021
Article in press: August 10, 2021
Published online: August 18, 2021
Processing time: 171 Days and 3.4 Hours
Core Tip
Core Tip: Upon closer inspection on respiratory diseases, coronavirus disease 2019 (COVID-19), influenza, severe acute respiratory syndrome, and Middle East respiratory syndrome have similarities in pathogenesis, especially cytokine and immune response profiles. These comparable features in terms of the cytokine storm will provide hints for the treatment of COVID-19. Transplantation of mesenchymal stromal cells provides tissue regeneration and rejuvenation with immunotolerant and immunomodulant properties on damaged tissues by exerting their effects through immune cells.