Minireviews
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transplant. May 18, 2021; 11(5): 138-146
Published online May 18, 2021. doi: 10.5500/wjt.v11.i5.138
Transplantation of CD34+ cells for myocardial ischemia
Anthony Matta, Vanessa Nader, Michel Galinier, Jerome Roncalli
Anthony Matta, Vanessa Nader, Michel Galinier, Jerome Roncalli, Department of Cardiology, Institute CARDIOMET, University Hospital of Toulouse, Toulouse 31059, France
Anthony Matta, Faculty of Medicine, Holy Spirit University of Kaslik, Kaslik 00000, Lebanon
Vanessa Nader, Faculty of Pharmacy, Lebanese University, Beirut 961, Lebanon
Author contributions: Matta A contributed to conception, design and writing of the report; Nader V contributed to conception and design of the report; Galinier M revised the paper; Roncalli J contributed to design and writing of the report and provided important intellectual contributions to the study.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jerome Roncalli, MD, PhD, Full Professor, Department of Cardiology, Institute CARDIOMET, University Hospital of Toulouse, 1 Avenue Jean Poulhès, Toulouse 31059, France. roncalli.j@chu-toulouse.fr
Received: January 29, 2021
Peer-review started: January 29, 2021
First decision: February 25, 2021
Revised: March 1, 2021
Accepted: April 13, 2021
Article in press: April 13, 2021
Published online: May 18, 2021
Processing time: 107 Days and 22.9 Hours
Core Tip

Core Tip: CD34+ cells are mobilized from the bone marrow into the peripheral circulation in response to ischemic tissue injury. Once they migrate to the target site, they enhance angiogenesis, neovascularization and tissue regeneration. Safety and efficacy of CD34+ cell transplantation has been investigated in order to limit left ventricular dysfunction after acute myocardial infarction, refractory angina and heart failure.