©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transplant. Sep 18, 2020; 10(9): 256-266
Published online Sep 18, 2020. doi: 10.5500/wjt.v10.i9.256
Published online Sep 18, 2020. doi: 10.5500/wjt.v10.i9.256
Liver transplantation and aging
Danko Mikulic, Department of Abdominal and Transplant Surgery, Merkur University Hospital, Zagreb 10000, Croatia
Anna Mrzljak, Department of Medicine, Merkur University Hospital; School of Medicine, University of Zagreb, Zagreb 10000, Croatia
Author contributions: Mikulic D and Mrzljak A made contributions to the conception and design of the study, collecting of data and in drafting and revising the manuscript; both authors read and approved the final manuscript.
Conflict-of-interest statement: No potential conflicts of interest.
Corresponding author: Anna Mrzljak, MD, PhD, Associate Professor, Department of Medicine, Merkur University Hospital, Zajceva 19, Zagreb 10000, Croatia. anna.mrzljak@mef.hr
Received: April 4, 2020
Peer-review started: April 4, 2020
First decision: April 26, 2020
Revised: May 3, 2020
Accepted: July 19, 2020
Article in press: July 19, 2020
Published online: September 18, 2020
Processing time: 164 Days and 17.1 Hours
Peer-review started: April 4, 2020
First decision: April 26, 2020
Revised: May 3, 2020
Accepted: July 19, 2020
Article in press: July 19, 2020
Published online: September 18, 2020
Processing time: 164 Days and 17.1 Hours
Core Tip
Core Tip: An increase in the average life expectancy paralleled by a demographic shift in the population with end-stage liver disease raises the demand for liver transplantation (LT) among the elderly. The most common indications for LT such as hepatocellular carcinoma, alcohol-related liver disease, hepatitis C virus and non-alcoholic fatty liver disease tend to affect older patients more and more. However, risks need to be weighed against the benefits since the effects of associated age-related co-morbidities in older individuals may affect transplant outcomes.