Retrospective Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transplant. Jul 29, 2020; 10(7): 206-214
Published online Jul 29, 2020. doi: 10.5500/wjt.v10.i7.206
Anticoagulation in simultaneous pancreas kidney transplantation - On what basis?
Jeevan Prakash Gopal, Frank JMF Dor, Jeremy S Crane, Paul E Herbert, Vassilios E Papalois, Anand SR Muthusamy
Jeevan Prakash Gopal, Frank JMF Dor, Jeremy S Crane, Paul E Herbert, Vassilios E Papalois, Anand SR Muthusamy, Imperial College Renal and Transplant Center, Imperial College Healthcare NHS Trust, Hammersmith Hospital, London W12 0HS, United Kingdom
Frank JMF Dor, Jeremy S Crane, Paul E Herbert, Vassilios E Papalois, Anand SR Muthusamy, Department of Surgery and Cancer, Imperial College, London W12 0HS, United Kingdom
Author contributions: Muthusamy ASR conceived the study; Gopal JP collected the data, performed the analysis and wrote the manuscript; Dor FJMF, Crane JS, Herbert PE, Papalois VE, and Muthusamy ASR contributed to the data generation, reviewed the manuscript and made critical corrections to the manuscript.
Institutional review board statement: This study was reviewed and approved by the Imperial College Healthcare NHS Trust.
Informed consent statement: All the patients in the study have given their consent for clinical management as per the trust informed consent policy. Hence this study does not require individual patient consent.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Anand SR Muthusamy, FRCS, Consultant Transplant Surgeon, Imperial College Renal and Transplant Center, Imperial College Healthcare NHS Trust, Hammersmith Hospital, Du Cane Road, London W12 0HS, United Kingdom. anand.muthusamy@nhs.net
Received: January 16, 2020
Peer-review started: January 16, 2020
First decision: February 25, 2020
Revised: March 26, 2020
Accepted: June 14, 2020
Article in press: June 14, 2020
Published online: July 29, 2020
Processing time: 188 Days and 9 Hours
Core Tip

Core tip: Early post-operative graft thrombosis and graft loss are the Achilles heel of pancreas transplantation and routine prophylactic anticoagulation seems to be the logical remedy. Do all patients need the same dose of anticoagulation? We have compared the outcomes of thromboelastogram directed and conventional coagulation test based anticoagulation in simultaneous pancreas and kidney (SPK) transplant recipients and highlighted the needs and advantages of individualized anticoagulation based on thromboelastogram.