Ghazanfar A, Abbas M, Hussain MW, Kayal M. Risk stratification of renal transplant recipients using routine parameters: Implication of learning from SARS-CoV-2 into transplant follow-up program. World J Transplant 2023; 13(6): 344-356 [PMID: 38174144 DOI: 10.5500/wjt.v13.i6.344]
Corresponding Author of This Article
Abbas Ghazanfar, MBBS, FACS, FCPS, FEBS, FICS, FRCS, RCPathME, Chairman, Doctor, Researcher, Senior Lecturer, Surgeon, Renal and Transplant Unit, St Georges University Hospitals NHS Foundation Trust, London SW17 0QT, London SW17 0QT, United Kingdom. a.ghazanfar@nhs.net
Research Domain of This Article
Transplantation
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Transplant. Dec 18, 2023; 13(6): 344-356 Published online Dec 18, 2023. doi: 10.5500/wjt.v13.i6.344
Risk stratification of renal transplant recipients using routine parameters: Implication of learning from SARS-CoV-2 into transplant follow-up program
Abbas Ghazanfar, Madiha Abbas, Md Walid Hussain, Malik Kayal
Abbas Ghazanfar, Renal and Transplant Unit, St Georges University Hospitals NHS Foundation Trust, London SW17 0QT, United Kingdom
Madiha Abbas, Department of Anesthesia and Intensive Care Medicine, Epsom and St Helier University Hospitals NHS Trust, London KT8 7EG, United Kingdom
Md Walid Hussain, Malik Kayal, Department of Renal and Transplant Surgery, St Georges University Hospitals NHS Foundation Trust, London SW17 0QT, United Kingdom
Author contributions: Ghazanfar A and Abbas M contributed to study design, data analysis, manuscript writing; Ghazanfar A and Hussain Md W contributed to data collection; Kayal M contributed to manuscript writing support.
Institutional review board statement: Compliance with local ethical and data protection policies. Registered with St Georges University Hospitals NHS Foundation Trust Quality Assurance Department. Registration no AUD1000854.
Informed consent statement: Online assessment confirmed that no patient consent or ethical approval from NHS HRA/REC was required.
Conflict-of-interest statement: Authors have no conflict of interest related to the content of this publication.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at email address a.ghazanfar@nhs.net.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Abbas Ghazanfar, MBBS, FACS, FCPS, FEBS, FICS, FRCS, RCPathME, Chairman, Doctor, Researcher, Senior Lecturer, Surgeon, Renal and Transplant Unit, St Georges University Hospitals NHS Foundation Trust, London SW17 0QT, London SW17 0QT, United Kingdom. a.ghazanfar@nhs.net
Received: July 20, 2023 Peer-review started: July 20, 2023 First decision: September 5, 2023 Revised: October 21, 2023 Accepted: November 13, 2023 Article in press: November 13, 2023 Published online: December 18, 2023 Processing time: 150 Days and 19.7 Hours
ARTICLE HIGHLIGHTS
Research background
Various studies have been done to separately study routine laboratory markers to stratify patients with high risk of morbidity and mortality but very little is known in renal transplant patients.
Research motivation
This study provides a new way of looking at the significance of routine laboratory tests with an aim to risk stratify renal transplant recipients into high-risk sub-groups.
Research objectives
This study will help in shaping new policies and guidelines by providing individualized shielding advice, self-isolation guidance and booster coronavirus disease 2019 vaccination. Moreover, this will also help to plan better follow-up strategies for transplant patient. Addressing and correcting these parameters during a follow-up program can reduce the risk of morbidity and mortality in renal transplant recipients (RTxR).
Research methods
Retrospective observational study to analyze the data of our renal transplant follow-up program for various routine parameters and their impact of patient outcomes.
Research results
This study has identified some routinely used modifiable parameters in predicting a higher risk of mortality and morbidity.
Research conclusions
This knowledge can be used in RTxR follow-up programs by addressing these parameters early to help reduce the morbidity and mortality in RTxRs.
Research perspectives
This knowledge can be used in RTxR follow-up programs by addressing these parameters early to help reduce the morbidity and mortality in RTxRs.
