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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transplant. Feb 24, 2017; 7(1): 64-69
Published online Feb 24, 2017. doi: 10.5500/wjt.v7.i1.64
International kidney paired donation transplantations to increase kidney transplant of O group and highly sensitized patient: First report from India
Vivek B Kute, Himanshu V Patel, Pankaj R Shah, Pranjal R Modi, Veena R Shah, Sayyed J Rizvi, Bipin C Pal, Priya S Shah, Pavan S Wakhare, Saiprasad G Shinde, Vijay A Ghodela, Umesh T Varyani, Minaxi H Patel, Varsha B Trivedi, Hargovind L Trivedi
Vivek B Kute, Himanshu V Patel, Pankaj R Shah, Priya S Shah, Pavan S Wakhare, Saiprasad G Shinde, Vijay A Ghodela, Umesh T Varyani, Hargovind L Trivedi, Department of Nephrology and Clinical Transplantation, Institute of Kidney Diseases and Research Center, Dr HL Trivedi Institute of Transplantation Sciences (IKDRC-ITS), Ahmedabad 380016, India
Pranjal R Modi, Sayyed J Rizvi, Bipin C Pal, Department of Urology and transplantation, IKDRC-ITS, Ahmedabad 380016, India
Veena R Shah, Department of Anesthesia, IKDRC-ITS, Ahmedabad 380016, India
Minaxi H Patel, Varsha B Trivedi, Department of Pathology, Laboratory Medicine, Transfusion Services and Immunohematology, IKDRC-ITS, Ahmedabad 380016, India
Author contributions: All authors contributed to this paper.
Institutional review board statement: The study was reviewed and approved by the Science and Research Office of IKDRC-ITS, Ahmedabad 380016 (India).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: There are no conflicts of interest to report.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Vivek B Kute, MBBS, MD, FCPS, DM Nephrology (Gold Medalist), FASN, Associate Professor, Department of Nephrology and Clinical Transplantation, Institute of Kidney Diseases and Research Center, Dr HL Trivedi Institute of Transplantation Sciences (IKDRC-ITS), Civil Hospital Campus, Asarwa, Ahmedabad 380016, India.
drvivekkute@rediffmail.com
Telephone: +91-90-99927543
Received: October 31, 2016
Peer-review started: November 2, 2016
First decision: November 14, 2016
Revised: November 18, 2016
Accepted: December 7, 2016
Article in press: December 9, 2016
Published online: February 24, 2017
Processing time: 113 Days and 0.7 Hours
AIM
To report the first international living related two way kidney paired donation (KPD) transplantation from India which occurred on 17th February 2015 after legal permission from authorization committee.
METHODS
Donor recipient pairs were from Portugal and India who were highly sensitized and ABO incompatible with their spouse respectively. The two donor recipient pairs had negative lymphocyte cross-matching, flow cross-match and donor specific antibody in two way kidney exchange with the intended KPD donor. Local KPD options were fully explored for Indian patient prior to embarking on international KPD.
RESULTS
Both pairs underwent simultaneous uneventful kidney transplant surgeries and creatinine was 1 mg/dL on tacrolimus based immunosuppression at 11 mo follow up. The uniqueness of these transplantations was that they are first international KPD transplantations in our center.
CONCLUSION
International KPD will increases quality and quantity of living donor kidney transplantation. This could be an important step to solving the kidney shortage with additional benefit of reduced costs, improved quality and increased access for difficult to match incompatible pairs like O blood group patient with non-O donor and sensitized patient. To the best of our knowledge this is first international KPD transplantation from India.
Core tip: Kidney paired donation (KPD) has rapidly increased the access to living donor kidney transplantation (LDKT) in the last decade. The participation in the international kidney exchange registries will expand the donor pool for kidney transplantation. We report first Indian international living related KPD transplantation which occurred on 17th February 2015 after legal permission from authorization committee between a pair from Portugal and India who were highly sensitized and ABO incompatible with their spouse respectively. International KPD will increases quality and quantity of LDKT. This could be an important step to solving the kidney shortage with additional benefit of reduced costs, improved quality and increased access for difficult to match incompatible pairs like O blood group patient with non-O donor and sensitized patient.
