Ayloo S, Armstrong J, Hurton S, Molinari M. Obesity and liver transplantation. World J Transplant 2015; 5(3): 95-101 [PMID: 26421262 DOI: 10.5500/wjt.v5.i3.95]
Corresponding Author of This Article
Michele Molinari, MD, MSc, Associate Professor, Department of Surgery, Dalhousie University, 1276 South Park Street, Office 6-302 Victoria General Hospital, Halifax, Nova Scotia B3H 2Y9, Canada. michele.molinari@cdha.nshealth.ca
Research Domain of This Article
Transplantation
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Transplant. Sep 24, 2015; 5(3): 95-101 Published online Sep 24, 2015. doi: 10.5500/wjt.v5.i3.95
Obesity and liver transplantation
Subhashini Ayloo, John Armstrong, Scott Hurton, Michele Molinari
Subhashini Ayloo, John Armstrong, Scott Hurton, Michele Molinari, Department of Surgery, Dalhousie University, Halifax, Nova Scotia B3H 2Y9, Canada
Author contributions: Ayloo S and Molinari M contributed to systematic literature review; Ayloo S and Molinari M wrote the manuscript; Armstrong J and Hurton S contributed to pictures and tables creation.
Conflict-of-interest statement: All the authors report no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Michele Molinari, MD, MSc, Associate Professor, Department of Surgery, Dalhousie University, 1276 South Park Street, Office 6-302 Victoria General Hospital, Halifax, Nova Scotia B3H 2Y9, Canada. michele.molinari@cdha.nshealth.ca
Telephone: +1-902-4737624 Fax: +1-902-4737639
Received: April 4, 2015 Peer-review started: April 5, 2015 First decision: June 3, 2015 Revised: July 6, 2015 Accepted: July 21, 2015 Article in press: August 7, 2015 Published online: September 24, 2015 Processing time: 173 Days and 12.5 Hours
Abstract
The percentage of overweight and obese patients (OPs) waiting for a liver transplant continues to increase. Despite the significant advances occurred in bariatric medicine, obesity is still considered a relative contraindication to liver transplantation (LT). The main aim of this review is to appraise the literature on the outcomes of OPs undergoing LT, treatments that might reduce their weight before, during or after surgery, and discuss some of the controversies and limitations of the current knowledge with the intent of highlighting areas where future research is needed.
Core tip: The prevalence of obesity in the general population has doubled and the number of obese patients (OPs) affected by end-stage liver disease has increased with the same pace. There is conflicting data on the outcomes of OPs undergoing liver transplantation (LT) and the main aim of this review is to appraise the literature on the outcomes of OPs undergoing LT, treatments that might reduce their weight before, during or after surgery, and discuss some of the controversies and limitations of the current knowledge with the intent of highlighting areas where future research is needed.
