Published online Dec 24, 2014. doi: 10.5500/wjt.v4.i4.243
Revised: July 11, 2014
Accepted: July 27, 2014
Published online: December 24, 2014
Processing time: 220 Days and 20.4 Hours
Innovative and exciting advances in the clinical science in solid organ transplantation continuously realize as the results of studies, clinical trials, international conferences, consensus conferences, new technologies and discoveries. This review will address to the full spectrum of news in transplantation, that verified by 2013. The key areas covered are the transplantation activity, with particular regards to the donors, the news for solid organs such as kidney, pancreas, liver, heart and lung, the news in immunosuppressive therapies, the news in the field of tolerance and some of the main complications following transplantation as infections and cancers. The period of time covered by the study starts from the international meetings held in 2012, whose results were published in 2013, up to the 2013 meetings, conferences and consensus published in the first months of 2014. In particular for every organ, the trends in numbers and survival have been reviewed as well as the most relevant problems such as organ preservation, ischemia reperfusion injuries, and rejections with particular regards to the antibody mediated rejection that involves all solid organs. The new drugs and strategies applied in organ transplantation have been divided into new way of using old drugs or strategies and drugs new not yet on the market, but on phase Ito III of clinical studies and trials.
Core tip: Basic and clinical science in solid organ transplantation are continuously evolving. In this review we outlined the most important innovative findings recently discovered. The period of time chosen was 2013, but attention has been paid to the outstanding conferences held in 2012, but published in 2013, as well as to the conferences and meetings held in 2013 but published in 2014. We are aware that when this study will be published, new interesting and relevant findings will have been discovered. The science is flowing continuously, nevertheless analyzing in depth a short period of time can give useful information to the readers.