Published online Aug 18, 2022. doi: 10.5500/wjt.v12.i8.268
Peer-review started: January 7, 2022
First decision: March 9, 2022
Revised: March 24, 2022
Accepted: August 5, 2022
Article in press: August 5, 2022
Published online: August 18, 2022
Processing time: 223 Days and 0.9 Hours
Patients with a history of solid organ transplantation (SOT) or hematopoietic stem cell transplantation (HSCT) are at an increased risk of developing post-transplant lymphoproliferative disorder (PTLD). The gastrointestinal (GI) tract is commonly affected as it has an abundance of B and T cells.
To determine typical GI-manifestations, risk factors for developing PTLD, and management.
Major databases were searched until November 2021.
Non-case report studies that described GI manifestations of PTLD, risk factors for developing PTLD, and management of PTLD were included. Nine articles written within the last 20 years were included in the review. All articles found that patients with a history of SOT, regardless of transplanted organ, have a prope
GI tract manifestations may be nonspecific; therefore, consideration of risk factors is crucial for identifying GI-PTLD. Like other lymphoma variants, PTLD is very aggressive making early diagnosis key to prognosis. Initial treatment is reduction of immunosuppression which is effective in more than 50% of cases; however, additional therapy including rituximab, chemotherapy, and surgery may also be required.
Core Tip: Patients with a history of solid-organ or hematopoietic stem cell transplantation are at an increased risk of developing post-transplant lymphoproliferative disorder (PTLD). The gastrointestinal (GI) tract is commonly affected as it has an abundance of B and T-cells. GI tract manifestations may be nonspecific; therefore, consideration of risk factors is crucial for identifying GI-PTLD. Like other lymphoma variants, PTLD is very aggressive making early diagnosis key to prognosis. Initial treatment is reduction of immunosuppression which is effective in more than 50% of cases; however, additional therapy including surgery and chemotherapy may also be required. We performed a systematic review of GI-PTLD to better describe GI manifestations, risk factors for disease, and management of GI-PTLD.