Thet MS, Verzelloni Sef A, Sef D. Can adequate hemodynamic management of brain-dead donors improve donor organ procurement? World J Transplant 2022; 12(4): 79-82 [PMID: 35633852 DOI: 10.5500/wjt.v12.i4.79]
Corresponding Author of This Article
Davorin Sef, MD, PhD, Surgeon, Department of Cardiothoracic Surgery and Transplant Unit, Harefield Hospital, Royal Brompton and Harefield Hospitals, Part of Guy’s and St Thomas’ NHS Foundation Trust, Hill End Road, London UB9 6JH, United Kingdom. davorin.sef@gmail.com
Research Domain of This Article
Transplantation
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Transplant. Apr 18, 2022; 12(4): 79-82 Published online Apr 18, 2022. doi: 10.5500/wjt.v12.i4.79
Can adequate hemodynamic management of brain-dead donors improve donor organ procurement?
Myat Soe Thet, Alessandra Verzelloni Sef, Davorin Sef
Myat Soe Thet, Department of Cardiac Surgery, St Bartholomew’s Hospital, London EC1A 7BE, United Kingdom
Myat Soe Thet, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London & Imperial College Healthcare NHS Trust, London W2 1NY, United Kingdom
Alessandra Verzelloni Sef, Department of Anaesthesia and Critical Care, Harefield Hospital, Royal Brompton and Harefield Hospitals, Part of Guy’s and St Thomas’ NHS Foundation Trust, London UB9 6JH, United Kingdom
Davorin Sef, Department of Cardiothoracic Surgery and Transplant Unit, Harefield Hospital, Royal Brompton and Harefield Hospitals, Part of Guy’s and St Thomas’ NHS Foundation Trust, London UB9 6JH, United Kingdom
Author contributions: Thet MS, Verzelloni Sef A and Sef D designed the research study; Thet MS wrote the original draft of the manuscript; Thet MS, Verzelloni Sef A and Sef D analyzed the literature and edited the draft of the manuscript; and all authors have read and approve the final manuscript.
Conflict-of-interest statement: The authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Davorin Sef, MD, PhD, Surgeon, Department of Cardiothoracic Surgery and Transplant Unit, Harefield Hospital, Royal Brompton and Harefield Hospitals, Part of Guy’s and St Thomas’ NHS Foundation Trust, Hill End Road, London UB9 6JH, United Kingdom. davorin.sef@gmail.com
Received: January 13, 2022 Peer-review started: January 13, 2022 First decision: March 16, 2022 Revised: March 19, 2022 Accepted: April 3, 2022 Article in press: April 3, 2022 Published online: April 18, 2022 Processing time: 90 Days and 6.5 Hours
Abstract
There is increasing evidence that adequate donor management with a goal of optimization of organ function is essential to maximize the number of organs that can be procured. Therefore, identification of the cause of hemodynamic instability is crucial in order to direct the right therapy. Several donor management goals for better hemodynamic management including serial echocardiography can guide hemodynamic management in potential donors to increase both number and quality of donor hearts.
Core Tip: There is increasing evidence that adequate donor management with a goal of optimization of organ function is essential to maximize the number of organs that can be procured. Early identification of potential donors and adequate donor management are essential in order to expand the donation pool and improve transplantable organ quality. The authors have summarized the available evidence on therapeutic strategies for hemodynamic management and monitoring.
