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World J Rheumatol. Nov 12, 2013; 3(3): 25-31
Published online Nov 12, 2013. doi: 10.5499/wjr.v3.i3.25
Published online Nov 12, 2013. doi: 10.5499/wjr.v3.i3.25
Role of Th17 cells in the pathogenesis of rheumatoid arthritis
Katia Boniface, Daniel Moynet, M Djavad Mossalayi, INSERM U1035, Dermatology group, Immunology Laboratory, Bordeaux Segalen University, 33076 Bordeaux Cedex, France
Author contributions: All the authors contributed to this paper equally.
Correspondence to: M Djavad Mossalayi, Professor, INSERM U1035, Dermatology group, Immunology Laboratory, Bordeaux Segalen University, 146, Rue Léo Saignat, 33076 Bordeaux Cedex, France. djavad.mossalayi@u-bordeaux2.fr
Telephone: + 33-547-304222 Fax: + 33-547-304222
Received: June 28, 2013
Revised: September 23, 2013
Accepted: October 17, 2013
Published online: November 12, 2013
Processing time: 143 Days and 17.5 Hours
Revised: September 23, 2013
Accepted: October 17, 2013
Published online: November 12, 2013
Processing time: 143 Days and 17.5 Hours
Core Tip
Core tip: identification of interleukin-17-producing cells (Th17) rise as important source of inflammatory cytokines, IL-17 in particular, with critical role during inflammatory diseases.In this paper, we reviewed the differentiation of these cells from naive lymphocytes, their role during inflammatory arthritis and therapeutic tools to control these cells.