Editorial
Copyright ©The Author(s) 2016.
World J Psychiatr. Mar 22, 2016; 6(1): 1-6
Published online Mar 22, 2016. doi: 10.5498/wjp.v6.i1.1
Table 1 Brain derived neurotrophic factor and common psychiatric disorders
Mental disordersResults and references
SchizophreniaPolymorphisms and BDNF[39]
The Val66Met allele association[40]
The TrkB receptor decreased in the hippocampus[41]
Up-[41] and down[42] regulated BDNF in the frontal cortices
Major depressive disorderAntidepressant increases BDNF levels[43]
BDNF protein increased in the NAc[44]
The decreased prefrontal cortex is correlated with decreased BDNF and TrkB levels[45,46]
BDNF dose-dependently decreases 5HT uptake[47]
Unclear whether BDNF polymorphisms contribute to expression of MDD symptoms or antidepressant efficacy[48,49]
BipolarBoth lithium and valproic acid increase BDNF expression in corticolimbic brain[40]
BDNF protein levels decreased in post mortem hippocampal tissue[40]
Serum BDNF levels decreased[49]
The V66M BDNF allele strongly correlated to BD[35,50]
PTSDPTSD risk associated with BDNF Val66Met and BDNF overexpression[15]
Blood BDNF levels and PTSD[4,15,18-21]