Copyright
©The Author(s) 2016.
World J Psychiatr. Mar 22, 2016; 6(1): 1-6
Published online Mar 22, 2016. doi: 10.5498/wjp.v6.i1.1
Published online Mar 22, 2016. doi: 10.5498/wjp.v6.i1.1
Mental disorders | Results and references |
Schizophrenia | Polymorphisms and BDNF[39] |
The Val66Met allele association[40] | |
The TrkB receptor decreased in the hippocampus[41] | |
Up-[41] and down[42] regulated BDNF in the frontal cortices | |
Major depressive disorder | Antidepressant increases BDNF levels[43] |
BDNF protein increased in the NAc[44] | |
The decreased prefrontal cortex is correlated with decreased BDNF and TrkB levels[45,46] | |
BDNF dose-dependently decreases 5HT uptake[47] | |
Unclear whether BDNF polymorphisms contribute to expression of MDD symptoms or antidepressant efficacy[48,49] | |
Bipolar | Both lithium and valproic acid increase BDNF expression in corticolimbic brain[40] |
BDNF protein levels decreased in post mortem hippocampal tissue[40] | |
Serum BDNF levels decreased[49] | |
The V66M BDNF allele strongly correlated to BD[35,50] | |
PTSD | PTSD risk associated with BDNF Val66Met and BDNF overexpression[15] |
Blood BDNF levels and PTSD[4,15,18-21] |
- Citation: Zhang L, Li XX, Hu XZ. Post-traumatic stress disorder risk and brain-derived neurotrophic factor Val66Met. World J Psychiatr 2016; 6(1): 1-6
- URL: https://www.wjgnet.com/2220-3206/full/v6/i1/1.htm
- DOI: https://dx.doi.org/10.5498/wjp.v6.i1.1