Memantine: New prospective in bipolar disorder treatment

Table 1 The analysis of relations between the diagnostic criteria of Manic Episode and other specific disorders

Manic episode→	A1	A2	A3	A4	A5	A6	A7	A8	A9	A10	A11	A12	A13	A14	A15	A16	A17	A18	A19	A20	A21	A22	A23	A24	A25
Other clinical disorders
D-1			x			x		x						x				x	x					x	x
D-2			x			x								x				x	x					x
D-3								x				x										x	x
D-4												x										x	x
D-5								x				x	x									x	x	x
D-6	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
D-7																							x
D-8			x						x					x				x	x			x
D-9			x						x					x				x	x
D-10	x		x				x	x	x	x	x	x	x	x		x	x	x	x			x
D-11			x
D-12			x						x					x
D-13			x						x					x
D-14			x						x					x				x	x
D-15			x						x					x
D-16													x
D-17			x
D-18																								x	x
D-19			x						x					x				x	x		x
D-20			x						x					x
D-21			x																	x				x	x
D-22																				x
D-23			x																	x					x
D-24			x																	x					x
D-25			x														x
D-26						x			x									x	x
D-27	x	x	x		x	x			x	x	x		x			x		x	x
D-28			x											x
D-29			x						x
D-30						x												x	x
D-31	x														x			x	x
D-32									x									x	x
D-33			x						x					x											x
D-34			x	x																x					x
D-35			x											x				x	x					x	x
D-36														x										x
D-37														x								x
D-38														x
D-39																									x
D-40								x														x
D-41			x	x																x				x	x
D-42			x																		x	x		x	x
D-43																	x				x
D-44			x				x	x
D-45																	x

D-6: It can have all the symptoms of Manic Episode; D-11: It can have many symptoms manic episode and dysthymia.

Table 2 Attributes of manic episode derived from the decomposition of the diagnostic criteria for manic episode DSM-5 and a review of the literature on the manic symptomatology

Attribute	Explanation
A1	Elevated mood
A2	Expansive mood
A3	Irritable mood and Aggressiveness
A4	Increased goal-directed activity
A5	Increased energy
A6	Hyperactivity
A7	Inflated self-esteem
A8	Grandiosity and bizarre ideas
A9	Decreased need for sleep or sleep disturbance
A10	More talkative than usual
A11	Pressure to keep talking
A12	Flight of ideas
A13	Subjective experience that thoughts are racing
A14	Distractibility
A15	Increased sociability
A16	Increased work or school activity
A17	Increased sexual activity or inappropriate sexually
A18	Psychic agitation
A19	Motor agitation
A20	Excessive involvement in activities with high potential for painful consequences
A21	Theatrically and exaggerated expression of emotion
A22	Psychotic features
A23	Catatonia
A24	Disinhibited behavior
A25	Impulsivity

Table 3 Clinical disorders with manic symptoms

Disorders	Abbreviation
Attention-deficit/hyperactivity disorder	D-1
Autism spectrum disorder	D-2
Brief psychotic disorder	D-3
Schizophreniform disorder	D-4
Schizophrenia	D-5
Schizoaffective disorder	D-6
Catatonia	D-7
Major depressive episode	D-8
Cyclothymic disorder	D-9
Depressive episode, with mixed features	D-10
Disruptive mood dysregulation disorder	D-11
Persistent depressive disorder (dysthymia)	D-12
Premenstrual dysphoric disorder	D-13
Recurrent brief depression	D-14
Generalized anxiety disorder	D-15
Obsessive-compulsive disorder	D-16
Reactive attachment disorder	D-17
Disinhibited social engagement disorder	D-18
Posttraumatic stress disorder	D-19
Acute stress disorder	D-20
Conduct disorder	D-21
Pyromania and kleptomania	D-22
Oppositional defiant disorder	D-23
Intermittent explosive disorder	D-24
Alcohol intoxication	D-25
Alcohol withdrawal	D-26
Caffeine intoxication	D-27
Caffeine withdrawal	D-28
Cannabis withdrawal	D-29
Sedative, hypnotic, or anxiolytic withdrawal	D-30
Stimulant intoxication	D-31
Stimulant withdrawal	D-32
Tobacco withdrawal	D-33
Gambling disorder	D-34
Alzheimer disorder	D-35
Fronto-temporal neurocognitive disorder	D-36
Lewy bodies disorder	D-37
Vascular neurocognitive disorder	D-38
General personality disorder	D-39
Schizotypal personality disorder	D-40
Antisocial personality disorder	D-41
Borderline personality disorder	D-42
Histrionic personality disorder	D-43
Narcissistic personality disorder	D-44
Paraphilic disorders	D-45

Diagnostic and statistical manual of mental disorder-5 containing one or more manic symptom.